Publications by authors named "N Lauzurica"
The prevalence of insulin resistance and type 2 diabetes increases with aging and these disorders are associated with inflammation. Insulin resistance and inflammation do not develop at the same time in all tissues. Adipose tissue is one of the tissues where inflammation and insulin resistance are established earlier during aging.
View Article and Find Full Text PDFDevelopment of liver fibrosis during aging: effects of caloric restriction.
J Biol Regul Homeost Agents
September 2013
Liver is the central metabolic organ of the body and diet is considered one of the main environmental factors that can impact on aging liver. In the elderly stage liver function is relatively well conserved although there are a variety of not well defined morphological changes related to liver fibrosis which is commonly associated with an inflammatory state. The aim of this paper is to study these alterations during the physiological process of aging in Wistar rats and also test if caloric restriction (CR) could ameliorate them.
View Article and Find Full Text PDFArticle Synopsis
- Serotonin (5-HT) plays a key role in regulating feeding behavior and is targeted by drugs like fluoxetine to treat eating disorders and aid weight loss.
- Acute fluoxetine administration in rats resulted in a significant reduction of food intake and body weight over five days, particularly notable in males, along with a decrease in retroperitoneal fat.
- While the drug did not change serotonin transporter (SERT) gene expression immediately, prolonged treatment increased SERT mRNA levels, suggesting a possible mechanism for fluoxetine's effects on binge eating and weight management.
Context: Insulin resistance and type 2 Diabetes have been associated to a low grade of inflammation and their prevalence increase with ageing.
Objective: To analyse the development of inflammation in adipose tissue, liver, muscle and hypothalamus during ageing and the effects of caloric restriction.
Materials And Methods: We have analysed the expression of inflammatory cytokines (TNFα, IL1-β, IL-12B and IL-6), proteins involved in macrophage recruitment (MCP-1, CCR2), TLR4 and macrophage markers (CD11c, CD11b and arginase1).
Article Synopsis
- Serotonin (5-HT) is crucial for regulating food intake and feeding behavior, and drugs that target the serotonin transporter (SERT) are used for treating eating disorders.
- A study involved female rats undergoing a restricted feeding/repletion protocol, showing that after a period of calorie restriction, they exhibited rebound hyperphagia (increased eating).
- Despite no changes in brain SERT levels from the diet changes, alterations in other eating behavior messengers were noted, suggesting new pathways for researching and developing treatments for eating behavior issues in humans following diet abandonment.