Publications by authors named "N Larsson"
Article Synopsis
- Lung adenocarcinoma is a serious cancer that is a major cause of death globally, and this study examines how mitochondrial DNA (mtDNA) copy number impacts tumor growth in mice.
- Increased mtDNA levels were found in lung tumors caused by KRAS expression, leading to larger tumors in mice with higher mtDNA and reduced growth when mtDNA was depleted.
- The findings suggest mtDNA copy number is critical for lung cancer progression and could pave the way for new cancer treatments, while immune responses in the lung remained unaffected by mtDNA levels.
In mammals, the leucine-rich pentatricopeptide repeat protein (LRPPRC) and the stem-loop interacting RNA-binding protein (SLIRP) form a complex in the mitochondrial matrix that is required throughout the life cycle of most mitochondrial mRNAs. Although pathogenic mutations in the LRPPRC and SLIRP genes cause devastating human mitochondrial diseases, the in vivo function of the corresponding proteins is incompletely understood. We show here that loss of SLIRP in mice causes a decrease of complex I levels whereas other OXPHOS complexes are unaffected.
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- The oxidative phosphorylation system in mitochondria is crucial for converting energy from food and can adapt its metabolism based on the body's needs or diseases.
- Oral treatment with an inhibitor of mitochondrial transcription (IMT) shifts metabolism in male mice towards burning fatty acids, leading to reduced body weight and improved liver and glucose health on a high-fat diet.
- The treatment causes a decrease in oxidative phosphorylation but increases fatty acid oxidation in the liver, suggesting a potential drug strategy for obesity and related health issues.