Publications by authors named "N Larochelle"
Article Synopsis
- Protein misfolding and mislocalization are key issues in both familial and sporadic ALS, making the maintenance of protein balance through heat shock proteins (HSPs) an important treatment strategy, but neurons have a high threshold for this response.
- In experiments with mouse models of ALS, the drugs arimoclomol and RGFP963 showed mixed results: they didn't increase HSP expression in FUS mice but helped improve cognitive function and dendritic spine density.
- In SOD1 mice, some HSPs were upregulated in muscle but not in spinal cord, with drug treatments enhancing muscle performance without promoting HSP expression, suggesting alternate
Article Synopsis
- * This study analyzed the expression of two specific HSPs, HSPA1A and HSPA8, in cultured motor neurons with ALS-linked variants (TDP-43, FUS, SOD1), finding poor induction of HSPA1A and lowered levels of HSPA8, which hampers protective chaperoning.
- * Treatments with histone deacetylase inhibitors proved more effective than the HSP coinducer arimoclomol in boosting HSP expression and ensuring neuronal health,
Article Synopsis
- * This study found that histone deacetylase (HDAC) inhibitors can enhance the heat shock response in spinal motor neurons under stress, especially when combined with other HSP-inducing drugs.
- * Different HDAC inhibitors showed varying effectiveness depending on the type of stress, but they were generally able to improve neuroprotection and reduce the effects of ALS-related mutations.
Introduction : application of evidence-based practice (EBP) by nurses is uneven and inconsistent. Background : characteristics related to head nurses and organizations influence their interventions to the detriment of EBP. Objectives : this integrative literature review informed by the knowledge-to-action (KTA) framework developed by Straus, Tetroe, and Graham (1) sought to identify the barriers and facilitators encountered by head nurses when implementing EBP among hospital staff nurses.
View Article and Find Full Text PDFStudy Objective: In rural settings, long distances and transport times pose a challenge for achieving early reperfusion goals in patients with ST-elevation myocardial infarction (STEMI). This study investigated the association between the method of pre-hospital 12-lead ECG transmission (radio transmission vs. cellular phone transmission) and the success of transmission and legibility of 12-lead ECGs in a rural setting.
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