Publications by authors named "N Langeland"
Article Synopsis
- The study aimed to compare immune responses to a COVID-19 booster vaccination between older adults and younger individuals, focusing on humoral and cellular immunity.
- Researchers found that older adults (average age 86) initially had lower immune responses after earlier vaccinations compared to younger adults (average age 39), but both groups improved their antibody levels after the booster.
- While young adults showed increased cellular immune responses after the booster, older adults did not, and their plasma showed higher levels of certain T cell activation and exhaustion markers, indicating potential immune dysfunction in the elderly.
Diarrhea claims >500,000 lives annually among children under five years of age in low- and middle-income countries. Mortality due to acute diarrhea (<7 days' duration) is decreasing, but prolonged (7-13 days) and persistent (≥14 days of duration) diarrhea remains a massive challenge. Here, we use a case-control study to decipher if fecal gut microbiota compositional differences between Ethiopian children with acute (n=554) or prolonged/persistent (n=95) diarrhea and frequency-matched non-diarrheal controls (n=663) are linked to diarrheal etiology.
View Article and Find Full Text PDFBackground: Patients with multiple sclerosis (MS) treated with anti-CD20 therapies such as rituximab may have increased risk of severe COVID-19 disease. Vaccination induces protective immunity, but humoral vaccine response is known to be attenuated in rituximab-treated MS-patients-patients, which has indicated a need for real world data on severe morbidity and mortality from COVID-19 after vaccination.
Methods: Rituximab-treated patients treated at Haukeland University Hospital were identified through the National MS Registry and invited to participate in the study by giving a consent and providing a blood sample 3 weeks or later after ordinary COVID-19- vaccination, i.
Background: Typhoid fever is a common cause of febrile illness in low- and middle-income countries. While multidrug-resistant (MDR) Salmonella Typhi (S. Typhi) has spread globally, fluoroquinolone resistance has mainly affected Asia.
View Article and Find Full Text PDFIntroduction: A substantial proportion of the over 700 million COVID-19 cases world-wide experience long-term symptoms. The objectives of this study were to compare symptom trajectories and risk factors for post-COVID-19 condition after Delta and Omicron infection.
Methods: This study consecutively recruited patients with SARS-CoV-2 infection from November 2021 to March 2022.