Publications by authors named "N Langebeek"
Background: Antiretroviral therapy (ART), which is increasingly used by people with HIV, accounts for significant care costs, particularly because of single-tablet regimens (STRs). This study explored de-simplification to a two-tablet regimen (TTR) for cost reduction. The objectives of this study were: (1) acceptance of de-simplification, (2) patient-reported outcomes, and (3) cost savings.
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- The COVIH study investigated the effects of an additional mRNA-1273 COVID-19 vaccination on immune responses in 1154 people living with HIV, particularly focusing on those with reduced antibody levels after their initial vaccinations.
- Results showed that 97% of participants significantly increased their antibody levels, with reported increases from 35 to 4317 binding antibody units per mL following the booster shot.
- The study concluded that the extra mRNA-1273 vaccination effectively enhanced immune responses, including T and B cell activation, in individuals who previously displayed weak responses to COVID-19 vaccines.
Article Synopsis
- - The study aims to enhance HIV care by standardizing the measurement of patient-reported outcomes alongside traditional clinical markers, responding to a global trend emphasizing what matters most to patients.
- - An international group of 37 experts and patients collaborated to identify and agree on a core set of outcomes, using a literature review and interviews, ultimately narrowing it down to 156 identified outcomes.
- - The newly developed HIV360 outcome set includes a combination of patient-reported and clinician-reported measures, along with risk-adjustment variables, allowing for improved recording and comparison across treatment sites to enhance quality in HIV care.
Background: HIV-infected individuals may be at risk for the premature onset of age-associated noncommunicable comorbidities. Being HIV-positive, having comorbidities and being of higher age may adversely impact health-related quality of life (HRQL). We investigated the possible contribution of HIV infection, comorbidities and age on HRQL and depression.
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