Publications by authors named "N Laksiri"

Background: Carotid free-floating thrombus (CFFT) is an uncommon disorder. The aim of this study was to describe a French cohort of CFFT patients.

Methods: We conducted a retrospective monocentric study from a Stroke Center among patients admitted for stroke with CFFT.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the effectiveness of endovascular therapy (EVT) compared to intravenous thrombolysis (IVT) in patients with a minor acute ischemic stroke and large vessel occlusion, specifically focusing on the National Institutes of Health Stroke Scale (NIHSS) scores.
  • Data was collected from 533 patients treated between 2005 and 2021, showing that while 25.5% received bridging therapy, only facial palsy on admission associated more with excellent outcomes in those receiving IVT alone.
  • The analysis concluded that NIHSS subitems were not significant predictors of patients who would benefit from EVT over IVT alone, indicating a need for further research in this area.
View Article and Find Full Text PDF

Background: We recently reported a worrying 30% rate of early neurological deterioration (END) occurring within 24 hours following intravenous thrombolysis (IVT) in minor stroke with isolated internal carotid artery occlusion (ie, without additional intracranial occlusion), mainly due to artery-to-artery embolism. Here, we hypothesize that in this setting IVT-as compared to no-IVT-may foster END, in particular by favoring artery-to-artery embolism from thrombus fragmentation.

Methods: From a large multicenter retrospective database, we compared minor stroke (National Institutes of Health Stroke Scale score <6) isolated internal carotid artery occlusion patients treated within 4.

View Article and Find Full Text PDF

Background: Whether bridging therapy (intravenous thrombolysis [IVT] followed by mechanical thrombectomy) is superior to IVT alone in minor stroke with large vessel occlusion is unknown. Perfusion imaging may identify subsets of large vessel occlusion-related minor stroke patients with distinct response to bridging therapy.

Methods: We conducted a multicenter international observational study of consecutive IVT-treated patients with minor stroke (National Institutes of Health Stroke Scale score ≤5) who had an anterior circulation large vessel occlusion and perfusion imaging performed before IVT, with a subset undergoing immediate thrombectomy.

View Article and Find Full Text PDF

Importance: The best reperfusion strategy in patients with acute minor stroke and large vessel occlusion (LVO) is unknown. Accurately predicting early neurological deterioration of presumed ischemic origin (ENDi) following intravenous thrombolysis (IVT) in this population may help to select candidates for immediate transfer for additional thrombectomy.

Objective: To develop and validate an easily applicable predictive score of ENDi following IVT in patients with minor stroke and LVO.

View Article and Find Full Text PDF