A novel USP4 inhibitor that suppresses colorectal cancer stemness by promoting β-catenin and Twist1 degradation.

Background: The high mortality rate of metastatic colorectal cancer (CRC) is primarily attributed to resistance to chemotherapy, where cancer stem cells (CSCs) play a crucial role. Deubiquitinating enzymes are essential regulators of CSC maintenance, making them potential targets for eliminating CSCs and overcoming chemotherapy resistance. This study aims to identify key deubiquitinating enzymes regulating CSCs and drug resistance of CRC.

Radiomics for prediction of perineural invasion in colorectal cancer: a systematic review and meta-analysis.

Background: Perineural invasion (PNI) in colorectal cancer (CRC) is a significant prognostic factor associated with poor outcomes. Radiomics, which involves extracting quantitative features from medical imaging, has emerged as a potential tool for predicting PNI. This systematic review and meta-analysis aimed to evaluate the diagnostic accuracy of radiomics models in predicting PNI in CRC.

Knowledge, Attitude, and Practice Toward Pelvic Floor Dysfunction Among Postpartum and Postmenopausal Women: A Cross-sectional Study.

Introduction And Hypothesis: This research sought to explore the knowledge, attitude, and practice (KAP) toward pelvic floor dysfunction (PFD) among postpartum and postmenopausal women.

Methods: This cross-sectional study was performed among postpartum and postmenopausal women between May and August 2023. Demographic data, along with KAP scores, were collected using a self-designed questionnaire-based approach.

The molecular mechanism of transforming red light signal to (E)-β-caryophyllene biosynthesis in Arabidopsis.

It is known that red light irradiation enhances the biosynthesis of (E)-β-caryophyllene in plants. However, the underlying mechanism connecting red light to (E)-β-caryophyllene biosynthesis remains elusive. This study reveals a molecular cascade involving the phyB-PIF4-MYC2 module, which regulates (E)-β-caryophyllene biosynthesis in response to the red light signal in Arabidopsis thaliana.

Sex-specific cut-off for dilute Russell's viper venom time lupus anticoagulant test may be of value.

Background: Current guidelines recommend application of the 99th percentile to determine the cut-off value on at least 120 healthy donors regardless of sex for lupus anticoagulant (LA) ratio of each step. However, a statistically significant difference between the sexes has been found for LA ratio recently.

Objectives: To clarify whether this sex difference in dilute Russell's viper venom time (DRVVT) exists in various detection systems and the necessity of setting sex-specific cut-off values.