Antiedemic Effect of the Myosin Light Chain Kinase Inhibitor PIK7 in the Rat Model of Myocardial Ischemia Reperfusion Injury.

Myocardial ischemia-reperfusion injury increases myocardial microvascular permeability, leading to enhanced microvascular filtration and interstitial fluid accumulation that is associated with greater microvascular obstruction and inadequate myocardial perfusion. A burst of reactive oxygen species and inflammatory mediators during reperfusion causes myosin light chain kinase (MLCK)-dependent endothelial hyperpermeability, which is considered a preventable cause of reperfusion injury. In the present study, a single intravenous injection of MLCK peptide inhibitor PIK7 (2.

Lipid Profile of Mayr in Adaptation to Natural Conditions in the Cryolithozone.

The prevalence of coniferous trees in the forest landscapes of northeastern Siberia is conditioned by their high frost resistance. The Kajander larch ( Mayr), which can survive under natural conditions (down to -60 °C) in the cryolithozone of Yakutia, is the dominant forest-forming species. We hypothesise that our study using HPTLC-UV/Vis/FLD, TLC-GC/FID, and GC-MS methods of seasonal features of the lipid profile of Kajander larch tissues will bring us closer to understanding the mechanisms of participation of lipid components in the adaptation of this valuable tree species to the cold climate of the cryolithozone.

[Long-term outcomes after endoscopic treatment of patients with Zenker's diverticulum].

Objective: To assess the long-term outcomes after endoscopic treatment of patients with Zenker's diverticulum.

Material And Methods: A single-center retrospective study included 207 patients with Zenker's diverticulum who underwent surgery between July 2014 and November 2021. There were 213 interventions including surgeries for recurrence.

[Carbonyl stress in menopausal women with insomnia].

Objective: To assess the level of advanced oxidation protein products (AOPP) and advanced glycation end products (AGEs) in menopausal women with insomnia.

Material And Methods: One hundred and thirty-six menopausal women were examined. After collecting medical history, general clinical examination, examination by a gynecologist and identifying the presence and nature of sleep disorders, the subjects were divided into 4 groups: 1 - control/perimenopause (=21); 2 - insomnia/perimenopause (=34); 3 - control/postmenopause (=31); 4 - insomnia/postmenopause (=50).

[Metabolic syndrome and antipsychotic therapy of schizophrenia].

The review article discusses the relationship of metabolic disorders with schizophrenia and antipsychotic therapy, the importance of metabolic syndrome for the health of patients with schizophrenia. Risk factors for the development of metabolic syndrome are considered. The metabolic side effects of various antipsychotics are characterized.