Chemoimmunotherapy-Resistant Ocular Surface Squamous Neoplasia Managed With I-125 Brachytherapy.

Purpose: The purpose of this study was to report the management of chemoimmunotherapy-resistant ocular surface squamous neoplasia (OSSN) with iodine-125 (I-125) brachytherapy.

Methods: A 36-year-old man presented to the clinic with biopsy-proven OSSN that covered ∼70% of the corneal surface and extended to the 6 o'clock position of the inferior limbus of the OS. The visual acuity was 20/20 in the OD and 20/40 in the affected OS.

Venous Endothelial Cell Transcriptomic Profiling Implicates METAP1 in Preeclampsia.

Background: Preeclampsia is a hypertensive disorder of pregnancy characterized by systemic endothelial dysfunction. The pathophysiology of preeclampsia remains incompletely understood. This study used human venous endothelial cell (EC) transcriptional profiling to investigate potential novel mechanisms underlying EC dysfunction in preeclampsia.

So Many Injections, So Much Waste: Understanding the Environmental Impact of Intravitreal Injections.

To understand the environmental burden associated with intravitreal injections (IVIs) and propose actionable solutions to mitigate this impact. An analysis of current IVI practices was conducted, focusing on packaging waste, energy consumption, the carbon footprint, and disposal processes. Data on the environmental footprint of IVIs were collected from the literature and industry reports.

Factors and outcomes associated with under- and overdiagnosis of sepsis in the first hour of emergency department care.

Background: Sepsis remains the leading cause of in-hospital death and one of the costliest inpatient conditions in the United States, while treatment delays worsen outcomes. We sought to determine factors and outcomes associated with a missed emergency physician (EP) diagnosis of sepsis.

Methods: We conducted a secondary analysis of a prospective single-center observational cohort of undifferentiated, critically ill medical patients (September 2020-May 2022).

Vision recovery after ocular massage for cosmetic filler-induced ophthalmic artery occlusion.

Purpose: To report a case of vision recovery after ocular massage for cosmetic filler-induced ophthalmic artery occlusion.

Observations: A 58-year-old female experienced acute loss of vision of the left eye, left ptosis, and left glabellar skin discoloration immediately after cosmetic filler injection, suggestive of occlusion of the branches of the ophthalmic artery. Highly aggressive, prolonged ocular massage was initiated soon after and followed by a substantial recovery of vision.