Gene expression associated with endocrine therapy resistance in estrogen receptor-positive breast cancer.

Despite endocrine therapy (ET), approximately 20-40% of Stage I-III estrogen receptor-positive breast cancer (ER + BC) patients experience recurrence. Recurrence while on ET is indicative of ET resistance. This study aimed to identify differentially expressed genes (DEGs) associated with recurrence during ET (ET resistance) and to explore gene expression differences across PAM50 molecular subtypes.

Variant-specific antibody correlates of protection against SARS-CoV-2 Omicron symptomatic overall infections.

Background: Vaccination prior infection elicit neutralizing antibodies targeting SARS-CoV-2, yet the quantitative relationship between serum antibodies infection risk against viral variants remains uncertain, particularly in underrepresented regions.

Methods: We investigated the protective correlation of pre-exposure serum neutralizing antibody levels, employing a panel of SARS-CoV-2 pseudoviruses (Omicron BA.1, Omicron BA.

Polyextremotolerant, opportunistic, and melanin-driven resilient black yeast Exophiala dermatitidis in environmental and clinical contexts.

Exophiala dermatitidis, a polyextremotolerant black yeast, thrives in diverse natural and human-made environments. Additionally, it is an opportunistic pathogen, capable of infecting immunocompromised individuals, particularly causing neurotropic infections. This study examined 41  E.

Central American and Caribbean consensus for the treatment of MS, NMOSD, and MOGAD.

Background: In recent years, significant progress has been made in immune demyelinating disorders, particularly regarding early diagnosis and disease-modifying drugs (DMDs). Despite advancements, socioeconomic factors in many Latin American countries present unique challenges that impede the proper identification and management of these disorders.

Objectives: The updated consensus from the Central American and Caribbean working group strives to enhance the management of Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorder (NMOSD), and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD) by offering a framework for incorporating available treatment into clinical practice.

TMEM160 Promotes Tumor Growth in Lung Adenocarcinoma and Cervical Adenocarcinoma Cell Lines.

The Chromosome-Centric Human Proteome Project (C-HPP) is an international initiative. It aims to create a protein list expressed in human cells by each chromosomal and mitochondrial DNA to enhance our understanding of disease mechanisms, akin to the gene list generated by the Human Genome Project. Transmembrane protein 160 (TMEM160) is a member of the transmembrane proteins (TMEM) family.