Publications by authors named "N L Sala"
Ameloblastoma, a benign yet aggressive odontogenic tumor known for its recurrence and the severe morbidity from radical surgeries, may benefit from advancements in targeted therapy. We present a case of a 15-year-old girl with ameloblastoma successfully treated with targeted therapy and review the literature with this question: Is anti-MAPK targeted therapy safe and effective for treating ameloblastoma? This systematic review was registered in PROSPERO, adhered to PRISMA guidelines, and searched multiple databases up to December 2023, identifying 13 relevant studies out of 647 records, covering 23 patients treated with MAPK inhibitor therapies. The results were promising as nearly all patients showed a positive treatment response, with four achieving complete radiological remission and others showing substantial reductions in primary, recurrent, and metastatic ameloblastoma sizes.
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- The Iberian Peninsula played a crucial role in understanding human settlement in Eurasia, particularly during the transition from Neandertals to anatomically modern humans.
- There was a notable lack of human presence in central Iberia for about 16,000 years following the Neandertals' disappearance until evidence of human occupation re-emerges around 36,200 years ago.
- The findings indicate that despite a shift towards colder and dryer conditions, anatomically modern humans successfully adapted their subsistence strategies and settled in areas previously thought to be uninhabitable, challenging existing views on early population dynamics in southwestern Europe.
How the Sima de los Huesos was won.
Anat Rec (Hoboken)
July 2024
Article Synopsis
- The Sima de los Huesos site, discovered in 1976 and excavated systematically since 1984, is dated between 430,000 and 300,000 years ago and has yielded over 7,000 human fossils, the largest find before Homo sapiens.
- The fossils represent at least 29 individuals of varied ages and sexes, and studies suggest a close relationship to Homo neanderthalensis.
- Key findings include insights into body size, evidence of intentional burial, care for disabled individuals, and indications of complex oral communication similar to modern humans.
Background: CDH1 and CTNNA1 remain as the main genes for hereditary gastric cancer. However, they only explain a small fraction of gastric cancer cases with suspected inherited basis. In this study, we aimed to identify new hereditary genes for early-onset gastric cancer patients (EOGC; < 50 years old).
View Article and Find Full Text PDFObjective: Assess the risk associated with COVID-19 in pregnant women on maternal and neonatal outcomes in Catalonia (Spain) in 2020, before the beginning of COVID-19 vaccination campaign.
Method: Cross-sectional descriptive study with all pregnant women (41,560) and their live newborns (42,097) (1st March to 31st December 2020). Women were classified: positive and negative COVID-19 diagnosis during pregnancy.