Financial toxicity in patients with gynecologic malignancies: a cross sectional study.

Objective: To evaluate financial toxicity and assess its risk factors among patients with gynecologic cancers.

Methods: This is a cross sectional study that included 2 survey tools, as well as patient demographics, disease characteristics, and treatment regimen. Financial toxicity is measured by validated Comprehensive Score for Financial Toxicity (COST) tool.

[Comparative study of effects of cortical nucleus of amygdala and pyriform cortex on activity of bulbar respiratory neurons in cats].

Comparative microelectrophysiological study of character and peculiarities of effects of the cortical nucleus of amygdala and of the periamygdalar area of pyriform cortex on impulse activity was performed on the same single functionally identified respiratory medullar neurons. A high reactivity of bulbar respiratory neurons on stimulation is established in both studied limbic structures. There is established the qualitatively different character of their response reactions at stimulation of the cortical amygdala nucleus and the periamygdalar cortex.

[The neuronal organization of the limbic (cingulo-)-visceral reflex arc].

The paper summarizes new electrophysiological data concerning the structural-functional organization of the limbic cortex and role of the rostral limbic region of visceral functions. Here are presented the results of a series of electrophysiological investigation of the focus of localization in the supracallosal (area 24) and infracallosal (area 25) part of the anterior cingulate gyrus of evoked potentials of maximal amplitude and minimal latent period to stimulation of pelvic, splanchnic and sciatic nerves. It was shown that evoked potentials of maximal amplitude and minimal latent periods to stimulation of viscero-somatic nerves are recorded in the supragenual area 24 in comparison with the infragenual area 25 of the anterior limbic cortex.

[Involvement of amygdala central nucleus in the regulation of cardiovascular functions].

Effects of high frequency stimulation of the amygdala central nucleus involved a selective decrease in the activity: an increase in the activity of the inferior cardiac nerve and a simultaneous decrease in the activity of the vertebral nerve, as well as an obvious BP increase. Bilateral electrolytic lesions of the same amygdala structure accompanied with an overload of the higher nervous activity induced no hypertensions. The role of the amygdala central nucleus in control of cardiovascular functions is discussed.

[The characteristics of the neuronal organization of the sympathetic-activating and sympathetic-inhibiting mechanisms of the visceral area of the limbic cortex].

Effects of high frequency stimulation of dorsal and ventral regions of anterior area 25 of the limbic cortex on the tonic electrical activity of two postganglionic sympathetic nerves of stellate ganglion-inferior cardiac and vertebral nerves and arterial blood pressure were studied in anesthetized cats. It was revealed three types of medullary influences: generalized activation of both sympathetic nerves and pressor responses mainly in case of stimulation of ventral structures, generalized inhibition of electrical activity of both sympathetic nerves and depressor responses in case of stimulation of dorsal region of area 25 and selective modulation of activity, namely increase in activity of inferior cardiac nerve and simultaneous decrease of activity of vertebral nerve. According to data of our previous comparative studies of sympathetic responses of inferior and vertebral postganglionic nerves to stimulation of anterior and posterior hypothalamus as a working hypothesis it is supposed that the dorsal region of area 25 of limbic cortex is the analogy of trophotropic system of anterior hypothalamus, the ventral region--of ergotrophic system of posterior hypothalamus.