Publications by authors named "N L Leparskaya"
Article Synopsis
- The study aimed to evaluate the effectiveness of Melphalan as a treatment for proliferative vitreoretinopathy (PVR) in Chinchilla rabbits.
- Two groups of rabbits received different doses of Melphalan intravitreally, with both groups showing no PVR development in treated eyes compared to untreated ones.
- Group 1 (higher dose) exhibited significant retinal damage, while Group 2 (lower dose) showed less structural disruption, indicating a potential balance between efficacy and safety in using Melphalan.
Article Synopsis
- The study focused on how different types of fibroblasts contribute to the formation of epiretinal membranes in a rabbit model designed to mimic proliferative vitreoretinopathy (PVR).
- Researchers injected human skin fibroblasts into the eyes of Chinchilla rabbits and monitored them for a month, assessing changes through histological examination.
- Key findings indicated that the introduction of these fibroblasts led to significant anatomical and inflammatory changes, establishing a model that can be used to evaluate the effectiveness of treatments for PVR.
A model of proliferative vitreoretinopathy induced by simultaneous intravitreal injection of recombinant IL-1β and platelet concentrate is created and its main morphological manifestations are studied on Chinchilla rabbits. The model reflects pathogenesis of proliferative vitreoretinopathy: epiretinal membrane with the formation of retinal plication, traction detachment of the retina; moderate inflammatory reaction in the uveal tract, in the optic nerve infundibulum, in the vitreous body; intact structural elements of the retina, dissociation of the retinal pigmented epithelium cells with their subsequent migration. The model is adequate to the clinical picture of proliferative vitreoretinopathy in humans, which recommends it for experimental studies of the efficiency of drug therapy and prevention of this disease.
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