Publications by authors named "N L Lehman"
The focus of this work was to identify the optimal magnetic resonance imaging (MRI) contrast between orthotopic U-87 MG tumours and normal appearing brain with the eventual goal of treatment response monitoring. U-87 MG human glioblastoma cells were injected into the brain of RNU nude rats (n = 9). The rats were imaged at 7 T at three timepoints for all animals: 3-5, 7-9, and 11-13 days after implantation.
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- The study aimed to assess complications and mortality related to vagus nerve stimulation (VNS) used for drug-resistant epilepsy treatment.
- A total of 117 VNS procedures were analyzed over 23 years, revealing common early complications like hoarseness and cough, while fewer severe complications were noted, particularly among children with intellectual disabilities.
- Despite some risks and late complications, VNS therapy appears mostly safe for long-term use, with a suggestion that it may reduce the incidence of sudden unexpected death in epilepsy (SUDEP) over time.*
Article Synopsis
- Papillary tumor of the pineal region (PTPR) is a rare and unique tumor characterized by specific molecular and histopathologic features, with limited prior research on its variations and clinical presentations.
- In a study of 76 confirmed PTPR cases, researchers identified two main methylation groups (PTPR-A and PTPR-B) and further classified PTPR-B into two subtypes (B1 and B2) based on DNA methylation profiles and genomic variations.
- Clinical outcomes revealed that nearly half of the patients experienced tumor progression, with significant differences in outcomes among the identified subtypes, highlighting the tumor's molecular diversity and potential for recurrence.
Background: Gamma-delta (γδ) T cells comprise an important subset of human T cells, responding to viral and bacterial infections, and are significant for cancer immunosurveillance. Human γδ T cells are divided into 5 major subsets, namely Vδ1-Vδ5, of which the latter 3 have limited available literature. At present, Vδ2 is the most studied subpopulation.
View Article and Find Full Text PDFSRSF1 governs splicing of over 1500 mRNA transcripts. SRSF1 contains two RNA-recognition motifs (RRMs) and a C-terminal Arg/Ser-rich region (RS). It has been thought that SRSF1 RRMs exclusively recognize single-stranded exonic splicing enhancers, while RS lacks RNA-binding specificity.
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