[Clinical features of atopic asthma and their relation to the T-regulatory cells and total immunoglobulin E].

Allergic diseases are among the most popular in the world. Scientific hypothesis formation and multifactorial pathogenesis of atopic asthma (AA) is constantly updated. Our purpose of this study was to investigate the relationship of humoral and cellular immunity with features clinical and anamnestic data in patients AA.

[Clinical course and characteristics of cellular and humoral immunity in patients with allergic rhinitis].

In research the condition cellular and humoral immunity is defined at allergic rhinitis--AR (n = 45) for an estimation of mechanisms pathogeny this disease. The AR in 76% of cases has the hereditary nature mainly from outside mothers (36%), begins more often at children's and teenage age (88%) and in 44% is accompanied by other allergic pathology. In structure of a sensibilization of patients the allergic rhinitis the basic place is occupied with pollen, household, fungoid and epidermal allergens, allergic reaction (83% of cases) thus prevailed.

[Clinical effectiveness of metformin and ramipril combination in complex therapy of patients with metabolic syndrome].

6 monthly application of the combination of metformin with ramipril (1000 and 5 mg per day respectively) in complex treatment of metabolic syndrome (MS) leads to improvement of the clinical course of ischemic heart disease (decrease of quantity and duration of painful cardial attacks, depression of the functional class of an angina of exertion, decrease of displays of chronic heart failure), normalization of arterial pressure and decrease of an abdominal obesity which can be considered as prophylaxis of development of diabetes mellitus 2 types and its cardiovascular complications. Combination of metformin with ramipril in complex treatment of a MS is effective and safe option of therapy of MS.

[Immune elements of pathogenesis of multiorgan failure syndrome in newborns].

Expression of clusters determination of T-cells immune links (CD4, CD8, CD95) and level of interferon-alpha at newborns with multiorgan failure syndrome were investigated. It were shown supressive character of immune reactions and reduction the level of interferon-alpha in this contingent of patients.

[Relationship of toll-like receptors 2 and 4 genes polymorphisms with allergic diseases with increased levels of specific IgE].

The aim of the research was to identify the role of genes polymorphisms encoding TLR2 (NP_003255.2) and TLR4 (NP_612564.1) in the increase of the specific IgE production level and development of allergic diseases.