[Effect of chronic stimulation of the emotionogenic zones of the hypothalamus on the status of carbohydrate metabolism in the rabbit].

In chronic experiments on rabbits receiving for 3 months low doses of cholesterol (60 mg per 1 kg of body weight daily), a repeated prolonged (2 h daily) intermittent stimulation of negative and positive emotive zones of the hypothalamus through implanted electrodes (eliciting avoidance and self-stimulation reactions correspondingly),--resulted in uniform disturbances of carbohydrate metabolism. There was a significant reduction of glucose tolerance in comparison with the control group of rabbits with implanted electrodes, as well as a gradual development of a slight, but stable neurogenic hyperglycemia. Simultaneously, in both experimental rabbits groups there were an equal increase of alimentary hypercholesterolemia and a development of persistent neurogenic arterial hypertension.

[Effect of prolonged chronic stimulation of positive emotionogenic zones of the hypothalamus on blood lipid levels and arterial pressure].

Chronic experiments on rabbits with electrodes implanted into positive affective zones of the hypothalamus, which provided the reaction of self-stimulation during experimentation have shown that prolonged, discrete (over 2 hours daily), chronic (over 2 months stimulation of these zones in unrestrained animals does not cause stable changes in the content of blood lipids but lead to a significant lowering of arterial blood pressure. Continued stimulation (for one month more) together with daily feeding of rabbits with small doses of cholesterol (60 mg/kg bw) produced the same effect as the stimulation of the negative emotiogenic zones, namely, a greater increase of alimentary hypercholesterolemia than in animals of two control groups (non-operated and with implanted electrodes), as well as arterial blood pressure elevation.