Publications by authors named "N L Fuentes"
Objective: To compare the effectiveness of the awake-prone position on relevant clinical outcomes in patients with COVID-19-related acute respiratory failure requiring high-flow nasal oxygen between different waves in Argentina.
Methods: This multicenter, prospective cohort study included adult patients with COVID-19-related acute respiratory failure requiring high-flow nasal oxygen. The main exposure position was the awake-prone position (≥ 6 hours/day) compared to the non-prone position.
Cholesterol-enriched plasma membrane domains are known to serve as signaling platforms in a diverse array of cellular processes. However, the link between cholesterol homeostasis and mutant APC-KRas-associated colorectal tumorigenesis remains to be established. Thus, we investigated the impact of Apc-Kras on (i) colonocyte plasma membrane cholesterol homeostasis, order, and receptor nanoclustering, (ii) colonocyte cell proliferation, and (iii) whether these effects are modulated by select membrane active dietaries (MADs).
View Article and Find Full Text PDFAim: Our objective was to determine the factors associated with the successful maturation of arteriovenous fistulas during hemodialysis.
Material And Methods: This prospective study included patients treated with hemodialysis and predialysis patients. Clinical, biochemical, sociodemographic, vascular ultrasound mapping, flow-mediated dilatation, and surgical factors were analyzed.
Continuous monitoring of the hemodynamic coherence between macro and microcirculation is difficult at the bedside. We tested the role of photoplethysmography (PPG) to real-time assessment of microcirculation during extreme manipulation of macrohemodynamics induced by the cardiopulmonary bypass (CPB).We analyzed the alternating (AC) and direct (DC) components of the finger PPG in 12 patients undergoing cardiac surgery with CPB at five moments: (1) before-CPB; (2) CPB-start, at the transition from pulsatile to non-pulsatile blood flow; (3) CPB-aortic clamping, at a sudden decrease in pump blood flow and volemia.
View Article and Find Full Text PDFArticle Synopsis
- - The airway smooth muscle (ASM) cell's function in contraction and remodeling relies on changes in its cytoskeleton, shifting between a relaxed "fluid-like" state and a contractile "solid-like" state based on protein interactions.
- - The review explores the roles of various cytoskeletal components, such as actin and myosin, as well as factors that influence their behavior and how these interactions relate to the airway's extracellular matrix and the physical mechanics of airway movement.
- - The findings highlight new insights into the mechanisms of ASM cell activity, which could inform approaches to understanding and treating asthma-related airway obstruction.