Publications by authors named "N Kyritsis"
Article Synopsis
- - The study aimed to compare the motor examinations done by the clinical neurosurgery team with the ISNCSCI assessments, since the latter can be time-consuming and impractical during acute spinal cord injuries.
- - Researchers analyzed data from the TRACK-SCI registry, which included 72 pairs of motor examinations from 63 patients, and found strong correlations between the two methods, indicating that neurosurgery motor examinations can effectively substitute for ISNCSCI exams.
- - The results showed a very high agreement between the scores from both types of examinations with low bias, suggesting that clinical neurosurgery evaluations are reliable for assessing neurological function after spinal cord injuries.
Background: Although many molecules have been investigated as biomarkers for spinal cord injury (SCI) or ischemic stroke, none of them are specifically induced in central nervous system (CNS) neurons following injuries with low baseline expression. However, neuronal injury constitutes a major pathology associated with SCI or stroke and strongly correlates with neurological outcomes. Biomarkers characterized by low baseline expression and specific induction in neurons post-injury are likely to better correlate with injury severity and recovery, demonstrating higher sensitivity and specificity for CNS injuries compared to non-neuronal markers or pan-neuronal markers with constitutive expressions.
View Article and Find Full Text PDFObjective: Venous thromboembolism (VTE) following traumatic spinal cord injury (SCI) is a significant clinical concern. This study sought to determine the incidence of VTE and hemorrhagic complications among patients with SCI who received low-molecular-weight heparin (LMWH) within 24 hours of injury or surgery and identify variables that predict VTE using the prospective Transforming Research and Clinical Knowledge in SCI (TRACK-SCI) database.
Methods: The TRACK-SCI database was queried for individuals with traumatic SCI from 2015 to 2022.
Article Synopsis
- - This study utilized the TRACK-SCI database to assess complications and outcomes in elderly patients (≥ 65 years) following spinal cord injuries between 2015 and 2019 at UCSF.
- - Results revealed a high complication rate, with 100% of patients experiencing at least one complication—averaging about 6.6 each—primarily from cardiovascular and pulmonary issues, and a 10% in-hospital mortality rate.
- - The use of vasopressors for maintaining blood pressure was prevalent, notably correlating with higher cardiovascular complications, and only a small percentage (7.5%) showed neurological improvement by discharge.