Publications by authors named "N Kushlinskii"
Ovarian cancer (OC) develops asymptomatically and escapes diagnosis until advanced stages, the feature contributing to a higher mortality rate. New prospects of OC diagnosis and treatment have been opened in studies of the gene regulation mechanisms that involve long noncoding RNAs (lncRNAs) and identification of the lncRNA genes that are inhibited via methylation of the promoter region. A set of 122 samples of primary OC tumors was examined by methylation specific real-time PCR to assess the methylation level of the lncRNA genes PLUT, SNHG1, SNHG6, SNHG12, and TINCR.
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- The small nucleolar RNA host gene (SNHG) family may contribute to cancer development by creating long non-coding RNAs and affecting ribosome production and small nucleolar RNA formation.
- A study analyzing 122 ovarian cancer samples found significant increases in the methylation levels of five SNHG family lncRNA genes, linking these changes to factors like tumor progression and metastasis.
- Additionally, there was a notable co-methylation among four of these genes and predictions of their interactions with specific microRNAs, suggesting their collective role in ovarian cancer pathogenesis.
Cancer is a major global health problem. The type of malignant neoplasm and the potency of the immune response against tumors are two of the key factors influencing the outcome of the disease. The degree of tumor infiltration by lymphocytes plays an important role in antitumor response development, generally correlating with a favorable prognosis of treatment for certain cancers.
View Article and Find Full Text PDFTen Hypermethylated lncRNA Genes Are Specifically Involved in the Initiation, Progression, and Lymphatic and Peritoneal Metastasis of Epithelial Ovarian Cancer.
Int J Mol Sci
November 2024
Our work aimed to evaluate and differentiate the role of ten lncRNA genes (, , , , , , , , , and ) in the development and progression of epithelial ovarian cancer (EOC). A representative set of clinical samples was used: 140 primary tumors from patients without and with metastases and 59 peritoneal metastases. Using MS-qPCR, we demonstrated an increase in methylation levels of all ten lncRNA genes in tumors compared to normal tissues ( < 0.
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- The study focuses on improving the treatment of cancers in children by exploring metabolic markers for early detection of complications.
- It involved three patient groups: healthy children, children with various cancers without complications, and those with complications such as infections.
- Key findings showed that children with cancer had significant metabolic issues and that certain biomarkers like procalcitonin and presepsin were effective in predicting the risk of sepsis early on.