Publications by authors named "N Kucine"
Article Synopsis
- The study analyzes data from the Kids-DOTT trial to investigate the treatment and outcomes of children with cerebral sinovenous thrombosis (CSVT) compared to those with other types of venous thromboembolism (VTE).
- CSVT was found to be more common in neonates and young children, often linked to infections, while treatment involved varying durations of anticoagulation, with no significant difference in outcomes between 6 weeks and longer treatments.
- The findings suggest that 6 weeks of anticoagulant therapy is safe and effective for treating acute pediatric CSVT, but caution is advised in generalizing results due to the nature of subgroup analysis.
Article Synopsis
- * Follow-up showed that most positive aPL were transient or low titer, while 10% met criteria for antiphospholipid syndrome (APS), which was linked to a significantly higher risk of recurrent VTE.
- * The research highlights the need for further studies on managing VTE in children, particularly for those diagnosed with APS, given their higher recurrence risk.
Cytoreductive therapy is not routinely recommended for younger patients with polycythemia vera (PV) due to concern that treatment toxicity may outweigh therapeutic benefits. However, no systematic data support this approach. To support objective risk/benefit assessment of cytoreductive drugs in patients with PV aged <60 years (PV<60), this systematic review and meta-analysis was conducted to evaluate toxicity and disease-related complications in PV<60 treated with interferon alfa (rIFN-α) or hydroxyurea (HU).
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