Anticonvulsant activities of myo-inositol and scyllo-inositol on pentylenetetrazol induced seizures.

Myo-inositol (MI) and its isomers are used for the treatment of various neuropathological conditions. The purpose of the present research was to study anticonvulsant properties of MI and scyllo-inositol (SCI) on pentylenetetrazol (PTZ) induced seizures in rats. Half an hour after treatment with MI (30 mg/kg) or SCI (5 mg/kg) seizures were induced in Wistar rats with PTZ (60 mg/kg).

Myo-inositol treatment prevents biochemical changes triggered by kainate-induced status epilepticus.

Identification of the compounds preventing the biochemical changes underlying the epileptogenesis process is of great importance. We have previously shown that myo-inositol (MI) administration reduces kainic acid (KA) induced seizure scores. MI treatment effects on biochemical changes triggered by KA induced status epilepticus (SE) were investigated in the present study.

Effect of acoustic stimulation on GABAergic neurons in limbic structures of krushinskii-molodkina rats.

Quantitative study of GABAergic and main cells in the hippocampus and piriform cortex of Krushinskii-Molodkina rats was performed 1 month after the incidence of seizure activity evoked by acoustic stimulation. The number of neurons significantly decreased in both regions and, particularly, in the hippocampus and central area of the piriform cortex.

Effect of oleamide on pentylenetetrazole-induced seizures in rats.

Oleamide exhibits antiepileptic activity and significantly decreases the degree of pentylenetetrazole-induced seizures.

Effect of myo-inositol on convulsions induced by pentylenetetrazole and kainic acid in rats.

We studied the effect of myo-inositol on pentylenetetrazole and kainic acid-induced seizures in rats. Myo-inositol significantly reduced seizure activity.