Graphene Mitigates Nanoscale Tribochemical Wear of Silica Glass in Water.

Despite the ubiquitous use of glasses, their simultaneous susceptibility toward scratch-induced defects and atmospheric hydration deteriorates their mechanical and chemical durability. Here, it is demonstrated that the deposition of a few-layer graphene provides unprecedented wear resistance to silica glass in aqueous conditions. To this extent, nanoscale scratch tests are carried out on graphene-glass surfaces via contact-mode atomic force microscopy with chemically inert and reactive tips.

Modular functionalization of cellular nanodiscs enables targeted delivery of chemotherapeutics into tumors.

The effective delivery of chemotherapeutic drugs to tumor sites is critical for cancer treatment and remains a significant challenge. The advent of nanomedicine has provided additional avenues for altering the in vivo distribution of drug payloads and increasing tumor localization. More recently, cell-derived nanoparticles, with their biocompatibility and unique biointerfacing properties, have demonstrated considerable utility for drug delivery applications.

Enhanced Age-Dependent Motor Impairment in Males of Modeling Spinocerebellar Ataxia Type 1 Is Linked to Dysregulation of a Matrix Metalloproteinase.

Over the past two decades, has proven to be successful in modeling the polyglutamine (polyQ) (caused by CAG repeats) family of neurodegenerative disorders, including the faithful recapitulation of pathological features such as polyQ length-dependent formation of protein aggregates and progressive neuronal degeneration. In this study, pan-neuronal expression of human with long polyQ repeat of 82 amino acids was driven using an elav-GAL4 driver line. This would essentially model the polyQ disease spinocerebellar ataxia type 1 (SCA1).