Publications by authors named "N Kremer"
Phosphorylation of substrates by cyclin-dependent kinases (CDKs) is the driving force of cell cycle progression. Several CDK-activating cyclins are involved, yet how they contribute to substrate specificity is still poorly understood. Here, we discover that a positively charged pocket in cyclin B1, which is exclusively conserved within B-type cyclins and binds phosphorylated serine- or threonine-residues, is essential for correct execution of mitosis.
View Article and Find Full Text PDFEchocardiography of the right heart in pulmonary arterial hypertension: insights from the ULTRA RIGHT VALUE study.
Eur Heart J Imaging Methods Pract
January 2025
Aims: Outcome in pulmonary arterial hypertension (PAH) is determined by right ventricular (RV) function adaptation to increased afterload. Echocardiography is easily available to assist bedside evaluation of the RV. However, no agreement exists about the feasibility and most relevant measurements.
View Article and Find Full Text PDFLoss of right ventricular outflow function in pulmonary hypertension.
J Heart Lung Transplant
February 2025
Article Synopsis
- The study investigates the relationship between right ventricular outflow tract (RVOT) function and the severity of pulmonary hypertension (PH) using three-dimensional echocardiography.
- Findings show that patients with PH have a significantly lower median 3D RVOT ejection fraction (EF) compared to healthy controls, indicating compromised RVOT function.
- Patients with low RVOT-EF were more likely to be in higher risk categories and experienced worse clinical outcomes, suggesting that segmental RVOT analysis can help identify high-risk individuals even if their overall right ventricular function appears normal.