Publications by authors named "N Konishi"
Backgrounds: Currently, there is a lack of evidence of prehabilitation during neoadjuvant chemotherapy (NAC) to prevent pneumonia of older patients. This study aimed to investigate the association of preoperative physical fitness after NAC with post-esophagectomy pneumonia in older patients with locally advanced esophageal cancer (LAEC).
Methods: This single-center exploratory prospective cohort study included 80 patients aged ≥ 65 years with LAEC scheduled for curative esophagectomy after NAC between 2021 and 2023.
Background: Smartphone apps and wearable activity trackers are increasingly recognized for their potential to promote physical activity (PA). While studies suggest that the use of commercial mobile health tools is associated with higher PA levels, most existing evidence is cross-sectional, leaving a gap in longitudinal data.
Objective: This study aims to identify app-use patterns that are prospectively associated with increases in and maintenance of PA.
In older patients with locally advanced esophageal cancer (LAEC), loss of skeletal muscle mass during neoadjuvant chemotherapy (NAC) is associated with poor clinical outcomes. This study aimed to investigate factors associated with loss of skeletal muscle mass during NAC in older patients with LAEC. This was a single-center exploratory prospective cohort study.
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- Elderly individuals experience a decline in respiratory and cardiovascular functions, leading to higher rates of chronic diseases like heart disease and pneumonia, which are major causes of death in Japan.
- The study aimed to create a wearable monitoring system for vital signs, comparing its accuracy to recognized medical devices for measuring both systemic (like heart rate) and local parameters (like skin temperature).
- While the new device performed adequately, showing about 89% data acquisition accuracy, improvements are still needed for systemic parameter measurements to enhance accuracy to above 90%.
The effect of aging on the repeated-dose liver micronucleus assay using N-nitrosodipropylamine, quinoline, and carbendazim.
Mutat Res Genet Toxicol Environ Mutagen
October 2024
The repeated dose liver micronucleus (RDLMN) assay has been sufficiently validated in terms of the numbers and types of chemicals studied. However, it remains unclear whether aging affects assay results. The OECD Test Guideline 407 (Repeated Dose 28-Day Oral Toxicity Study in Rodents) indicates that dosing should begin as soon as feasible after weaning and in any event before 9 weeks of age.
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