Publications by authors named "N Koletsos"
Objectives: Systemic sclerosis (SSc) is a rare and complex autoimmune disease with significant complications. During the last few years, research interest focuses on the differences between female and male patients. However, there is a lack of data regarding the role of sex in the presence of small airway disease (SAD).
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- This study investigates rheumatoid arthritis-associated interstitial lung disease (RA-ILD) to understand how inflammation and lung injury occur, particularly through the role of neutrophil extracellular traps (NETs).
- It includes nine RA-ILD patients and nine healthy controls, measuring inflammatory markers and NET formation, as well as testing the effects of the medication nintedanib over 16 weeks.
- Results show that patients with RA-ILD have higher levels of certain inflammatory markers and NETs, and nintedanib treatment appears to reduce these markers, highlighting its potential effectiveness in managing the disease.
It is established that diabetes mellitus (DM) is characterized by increased cardiovascular risk associated with subclinical atherosclerosis as well as microvascular alterations. Laser speckle contrast analysis (LASCA) is an innovative, non-invasive method for assessing skin microvascular function. We sought to assess skin microvascular function in patients with type 2 DM and matched controls.
View Article and Find Full Text PDFObjective: To present the characteristics of patients with potential difficult-to-treat (D2T) PsA.
Methods: We used data from the Greek multicentre registry of PsA patients. D2T PsA was defined as follows: patients with at least 6 months' disease duration, who have failed to at least one conventional synthetic DMARD and at least two biologic DMARDs/targeted synthetic DMARDs with a different mechanism of action and have either at least moderate disease activity (MODA) defined as DAPSA (Disease Activity index in PSoriatic Arthritis) >14, and/or are not at minimal disease activity (MDA).
Introduction: Psoriasis is an inflammatory skin disease that in some cases is accompanied by systemic manifestations. Given the varied clinical manifestations, the term psoriatic disease probably better reflects the clinical picture of these patients.
Literature Review: In most cases, the skin lesions precede joint involvement as well as other potentially involved organs such as the intestine and the eye.