Publications by authors named "N Kohri"
Article Synopsis
- Cholinergic urticaria with hypohidrosis or anhidrosis (CUHA) causes symptoms like itching, tingling, and reduced sweating, negatively impacting quality of life.
- Current treatments include antihistamines, steroids, and therapies to promote sweating, but the effectiveness of hot baths specifically needed assessment.
- In a study with eight CUHA patients, hot baths improved symptoms for around half of the participants, suggesting it could be a viable treatment option without severe side effects.
Farnesoid X receptor (FXR) regulates bile acid synthesis, lipid metabolism, and glucose homeostasis in metabolic organs. FXR-knockout (FXR-KO) mice lacking the last exon of the FXR gene develop normally and display no prenatal and early postnatal lethality, whereas human patients with mutations in the DNA-binding domain of the FXR gene develop severe hepatic dysfunction. In this study, we generated novel FXR-KO mice lacking the DNA-binding domain of the FXR gene using CRISPR-Cas9 technology and evaluated their phenotypes.
View Article and Find Full Text PDF