Publications by authors named "N Klimowska-Nassar"
Background And Objective: Cytoreductive treatments for patients diagnosed with de novo synchronous metastatic hormone-sensitive prostate cancer (mHSPC) confer incremental survival benefits over systemic therapy, but these may lead to added toxicity and morbidity. Our objective was to determine patients' preferences for, and trade-offs between, additional cytoreductive prostate and metastasis-directed interventions.
Methods: A prospective multicentre discrete choice experiment trial was conducted at 30 hospitals in the UK between December 3, 2020 and January 25, 2023 (NCT04590976).
Article Synopsis
- The study aimed to compare biopsy recommendation rates and accuracy between the Prostate Imaging-Reporting and Data System version 2 (PI-RADSv2) and the Likert scale for detecting significant and insignificant prostate cancer in men aged 50-69 participating in the IP1-PROSTAGRAM trial.
- Men were screened using Prostagram MRI, and results showed that more patients were recommended for biopsy with the Likert scale compared to PI-RADSv2 when the MRI score was ≥3, though accuracy in detecting cancer was similar for both systems.
- The findings indicate that while the Likert scale may suggest more biopsy recommendations, both methods have comparable effectiveness in identifying clinically significant prostate cancer.
Background: The use of prostate-specific antigen (PSA) testing to screen for prostate cancer has been fraught with under- and overdiagnosis. Short, noncontrast magnetic resonance imaging (MRI) might detect more grade group ≥2 cancers with similar rates of biopsy.
Objective: To evaluate strategies that combined PSA and MRI to select men based in the community for a prostate biopsy.
Background: The IP1-PROSTAGRAM study showed that a short, non-contrast MRI detected more significant cancers with similar rates of biopsy compared to PSA. Herein, we compare the expected and perceived burden of PSA, MRI and ultrasound as screening tests.
Methods: IP1-PROSTAGRAM was a prospective, population-based, paired screening study of 408 men conducted at seven UK primary care practices and two imaging centres.