The aim of the study was to compare blood pressure levels at specific periods of pregnancy, antihypertensive treatment regimens, pregnancy and childbirth outcomes in women with CAH and GAG to develop a differentiated approach to the management of pregnant women with hypertension. A prospective cohort study was conducted on the dynamic observation of 110 pregnant women with hypertension on the basis of perinatal centers №1 and №3 of Nur-Sultan (Kazakhstan) in 2018-2019. The main method for monitoring blood pressure was an office measurement, which was carried out in a perinatal center with an Omron HEM-FL31-E apparatus in compliance with the ESC 2018 recommendations.
View Article and Find Full Text PDFThe neurotoxin β-N-methylamino-L-alanine (BMAA) produced naturally by cyanobacteria, diatoms and dinoflagellates can be transferred and accumulated up the food chain, and may be a risk factor for neurodegenerative diseases. This study provides the first systematic screening of BMAA exposure of a large population through the consumption of seafood sold in metropolitan markets. BMAA was distinguished from known isomers by liquid chromatography tandem mass spectrometry after acidic hydrolysis and derivatization.
View Article and Find Full Text PDFGlycosaminoglycans (GAGs) are linear polysaccharides, consisting of repeated disaccharide units, attached to core proteins in all multicellular organisms. Chondroitin sulfate (CS) and dermatan sulfate (DS) constitute a subgroup of sulfated GAGs for which the degree of sulfation varies between species and tissues. One major goal in GAG characterization is to correlate structure to function.
View Article and Find Full Text PDF