Publications by authors named "N Kino"
Primary aldosteronism is characterised by the excessive production of aldosterone, which is a key regulator of salt metabolism, and is the most common cause of secondary hypertension. Studies have investigated the association between primary aldosteronism and genetic alterations, with pathogenic mutations being identified. This includes a glycine-to-arginine substitution at position 151 (G151R) of the G protein-activated inward rectifier potassium (K) channel 4 (GIRK4), which is encoded by the gene.
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- * Initially misdiagnosed with ovarian cancer, the patient underwent chemotherapy and surgery but saw worsening of symptoms until a molecular analysis revealed the true cancer type and fusion gene rearrangement.
- * Treatment with alectinib, an ALK-tyrosine kinase inhibitor, resulted in an 18-month partial response without adverse effects, emphasizing the need for further research into fusion gene structures and their impact on drug response.
Purpose: Stereotactic body radiotherapy (SBRT) boost is a promising treatment for cervical cancer patients who are ineligible for intracavitary brachytherapy (ICBT). The aim of this multicenter, single-arm, phase I/II study was to prospectively evaluate the efficacy and toxicity of SBRT boost.
Materials And Methods: ICBT-ineligible patients with untreated cervical cancer were enrolled.
Article Synopsis
- The study investigates the genetic background, clinical features, and treatment options for low-grade and high-grade endometrial stromal sarcomas (LGESS and HGESS) and undifferentiated uterine sarcomas (UUS) in light of recent changes in classification and staging.
- The analysis included 72 LGESS, 25 HGESS, and 16 UUS patients, highlighting that LGESS has a 5-year overall survival (OS) rate of 94%, whereas HGESS and UUS rates are significantly lower at 53% and 25%, respectively.
- Key findings indicate that poor OS in LGESS is linked to advanced stage, incomplete surgery, and lack of progesterone receptors, while UUS has
Objective: To establish a quantitative method to evaluate the DNA methylation level of an immediate upstream region of major BRCA1 transcriptional start sites (TSSs), and to investigate whether methylation of the region is a prognostic factor in high-grade serous ovarian cancer patients after neoadjuvant chemotherapy.
Methods: Ninety-two FFPE samples of advanced high-grade serous ovarian cancers after neoadjuvant chemotherapy between 2011 and 2018 were used for mutation and methylation analysis. DNA methylation levels were assessed by pyrosequencing and DNA methylation microarray.