The aim of our study was to assess morphological changes in internal organs in a redox-induced model of alloxan diabetes in rats.According to the results of the study, the blood glucose level in rats began to increase 24 hours after the of alloxan administration, reached the maximum level on the 15th day of observation, and decreased on the 25-35 day, to the control level. In parallel with the increase in blood glucose level, an increase in the malondialdehyde (MDA) content in the blood serum was observed.
View Article and Find Full Text PDFBackground: Modulation of endothelial function is a therapeutic option to reduce some of the significant complications of hypertension. However, the relationship between endothelial dysfunction reduced nitric oxide (NO) production, and the development of hypertension is not fully understood. To establish a potential pathogenetic link between impaired NO synthesis and hypertension, we investigated the results of competitive interaction of the substrate of NO synthase, L-arginine, and its analog, an non-selective inhibitor of NO synthase, N-nitro-methyl ether-L-arginine (L-NAME), in experimental rats.
View Article and Find Full Text PDFModern research technologies in clinical practice, ultrasound, CT, MRI altered the widespread adoption of the essential conditions and pathological processes in early verification, which is the basis of timely and optimal treatment. Therefore, it is very important to reveal morphological characteristic of pathological changes in each organ, primarily in tumors, which determine the specificity of ultrasound and computer-tomography images. The review presents the information about the latest development relating to the results of radiological and histopathomorphological examinations.
View Article and Find Full Text PDFGeorgian Med News
September 2011
An innate intention of subjects to reach the leading position on a regular job scale substantially accentuates the interest to the training study processes. The country that owns well-educated physicians possesses a better chance to attain the superior position in medical managing innovations. The modern scientific knowledge has to invade systematically thus into the ordinary common practice.
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