Publications by authors named "N Khadraoui"
Article Synopsis
- Antibiotic resistance and biofilm formation in Gram-negative bacteria pose significant challenges for infection control, particularly through the Quorum Sensing (QS) mechanism.
- Myrtle leaf extract demonstrated a potent anti-QS effect, inhibiting 80% of violacein production and significantly reducing various virulence factors like biofilm formation and protease activity at sub-MIC concentrations.
- The study identified three phenolic compounds from the extract, with 3,5-di-galloylquinic acid showing the strongest interaction with the CviR QS receptor, indicating potential for developing new QS inhibitors against resistant pathogens.
Article Synopsis
- - The study evaluated the antioxidant, antibacterial, antiviral, and anti-inflammatory properties of various parts (flowers, leaves, seeds) of a specific plant using 80% methanol extraction and microdilution techniques.
- - Flower extracts demonstrated significant antimicrobial effectiveness against Gram-positive bacteria, as well as strong antioxidant and anti-inflammatory properties, with no toxic effects on macrophage cells.
- - Two beneficial molecules, 12α-hydroxydaturametelin B and daturametelin B, were identified from the flower extract, showing promising potential for treating inflammatory disorders through effective binding with pro-inflammatory agents.
Mycoplasma pneumoniae is a cell wall-deficient prokaryote, mainly known to colonize the human respiratory tract and to be endemic, with epidemic peaks every 6 years, in older children and young adults. Diagnosis of M. pneumoniae is challenging because of the fastidious nature of the pathogen and the possibility of asymptomatic carriage.
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- * A study analyzed the antibacterial and antibiofilm effects of Peganum harmala seed extract, revealing that its n-butanol extract was more effective against drug-resistant strains than traditional antibiotics.
- * The active compound identified as harmaline demonstrated both strong antibacterial properties and significant biofilm inhibition, making it a promising candidate for treating P. aeruginosa-related infections.
The aim of this study was to investigate antimicrobial and antioxidant activities of different fractions obtained from edible Tunisian Ziziphus Lotus leaves of Tozeur region. Different organic extracts were tested: cyclohexane, dichloromethane, ethyl acetate, n-butanol and water. Bio-guided fractionation revealed that dichloromethane fraction is the most active against S.
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