Publications by authors named "N Khadka"
Mechanical Properties of Eye Lens Cortical and Nuclear Membranes and the Whole Lens.
Invest Ophthalmol Vis Sci
January 2025
Purpose: To elucidate the mechanical properties of the bovine lens cortical membrane (CM), the nuclear membrane (NM) containing cholesterol bilayer domains (CBDs), and whole bovine lenses.
Methods: The total lipids (lipids plus cholesterol) from the cortex and nucleus of a single bovine lens were isolated using the monophasic methanol extraction method. Supported CMs and NMs were prepared from total lipids extracted from the cortex and nucleus, respectively, using a rapid solvent exchange method and probe-tip sonication, followed by the fusion of unilamellar vesicles on a flat, freshly cleaved mica surface.
Introduction: Promotion of child health during the first thousand days from conception to the child's second birthday is vital for survival, growth and development. Growth monitoring and promotion services are key to the early detection of growth faltering and preventing malnutrition and promoting child health. This study aimed to assess the utilization of Growth Monitoring and Promotion (GMP) services and its associated factors among young children in Gorkha district of Nepal.
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- - The study investigates how spinal cord stimulation (SCS) models that calculate electric fields (E-fields) can be more accurately represented by considering frequency-dependent properties of spinal tissues, rather than using the traditional quasi-static approximation (QSA), which overlooks important factors.
- - Researchers utilized a finite element method (FEM) to analyze E-fields for different stimulation controls and frequencies, comparing results with the QSA method across multiple locations in the spinal column and discovering that electrical properties significantly affect E-field magnitude.
- - Findings reveal that the mode of stimulation (voltage-controlled vs. current-controlled) influences the E-field's impact on spinal cord heating and waveform distortion, with voltage-controlled methods being more affected by the frequency-dependent properties than current
Article Synopsis
- Postpartum depression (PPD) is a serious condition impacting both mothers and children, making it essential to study trends and risk factors related to its prevalence.
- A recent study analyzed over 442,000 pregnancies from Kaiser Permanente Southern California between 2010 and 2021, examining the relationship between PPD and factors like race, ethnicity, and prepregnancy body mass index (BMI).
- Results showed that PPD rates doubled from 9.4% in 2010 to 19.0% in 2021, with the highest increases among Asian/Pacific Islander and non-Hispanic Black populations, and worsening rates were particularly noted in individuals with obesity.
Objective: This study aims to identify hemolytic disease of the fetus and newborn (HDFN) pregnancies using electronic health records (EHRs) from a large integrated health care system.
Study Design: A retrospective cohort study was performed among pregnant patients receiving obstetrical care at Kaiser Permanente Southern California health care system between January 1, 2008, and June 30, 2022. Using structured (diagnostic/procedural codes, medication, and laboratory records) and unstructured (clinical notes analyzed via natural language processing) data abstracted from EHRs, we extracted HDFN-specific "indicators" (maternal positive antibody test and abnormal antibody titer, maternal/infant HDFN diagnosis and blood transfusion, hydrops fetalis, infant intravenous immunoglobulin [IVIG] treatment, jaundice/phototherapy, and first administrated Rho[D] Immune Globulin) to identify potential HDFN pregnancies.