Associations of 24-hr Movement Behaviors With Cardiometabolic Risk Factors and Metabolic Syndrome in Adults Receiving Outpatient Rehabilitation: A Compositional Time-Use Analysis.

Background: Research suggests associations between physical activity, sedentary behavior, sleep, and metabolic syndrome, but most has focused on healthy populations and individual behaviors. We investigated associations of 24-hr movement behavior compositions with cardiometabolic risk factors and metabolic syndrome in adults receiving rehabilitation for other health conditions.

Method:  This cross-sectional study assessed 24-hr movement behaviors using thigh-worn accelerometers and metabolic outcomes via blood analyses in 145 adults attending outpatient rehabilitation.

General practitioners experience multi-level barriers to implementing recommended care for hip and knee osteoarthritis: a qualitative study.

Background: General practitioners (GPs) play a key role in managing osteoarthritis, including referring to appropriate management services. Physiotherapist-led osteoarthritis management programs and advanced practice triage services are effective, but GPs views on them are largely unknown. This study aimed to explore general practitioner perspectives on: (1) managing patients with hip and knee osteoarthritis, and (2) physiotherapy-led osteoarthritis care and referral pathways.

Structure and mechanism of the Zorya anti-phage defense system.

Zorya is a recently identified and widely distributed bacterial immune system that protects bacteria from viral (phage) infections. Three Zorya subtypes have been discovered, each containing predicted membrane-embedded ZorAB complexes paired with soluble subunits that differ among Zorya subtypes, notably ZorC and ZorD in type I Zorya systems. Here, we investigate the molecular basis of Zorya defense using cryo-electron microscopy, mutagenesis, fluorescence microscopy, proteomics, and functional studies.

Improving Lynch syndrome detection: a mixed-methods process evaluation of a hybrid type III effectiveness-implementation trial.

Introduction: Translating evidence-based practices into real-world healthcare settings is challenging, particularly in the rapidly evolving field of genomics. A pragmatic two-arm cluster-randomized clinical trial (Hide and Seek Project - HaSP) tested two implementation approaches for improving hereditary cancer referral practices with one key distinction: implementation strategies that were designed 1) explicitly using psychological theory, or 2) using healthcare professional intuition. This mixed-methods process evaluation aimed to provide insights into how and why change occurred by examining contextual determinants, identifying mechanisms of action, and exploring the role of theory.