Publications by authors named "N Karlsson"
Article Synopsis
- * Recent upgrades have unified their data submission systems and created an automatic cross-referencing mechanism to improve connectivity between the two repositories.
- * The integration allows for better reporting of liquid chromatography experiments and introduces new visualization features for unpublished results, enhancing the overall functionality for researchers.
To investigate if salivary O-linked glycans are altered in primary Sjögren's syndrome (pSS), and thus contributing to explain symptoms of oral dryness, and an impaired oral mucosal barrier function leading to changes in microbial metabolism and colonization by both pathogenic and commensal microorganisms and increased prevalence of oral diseases. O-linked oligosaccharides from stimulated whole saliva (SWS) samples from 24 patients with pSS, 38 patients with non-pSS sicca, and 23 healthy controls were analyzed using liquid chromatography mass spectrometer (LC-MS). Non-fractionated reduced and alkylated saliva was dot-blotted to PVDF-membrane and O-linked oligosaccharides were released using reductive beta-elimination.
View Article and Find Full Text PDFBackground: Primary healthcare, the first line of care in many countries, treats patients with diverse health problems. High workload, time pressure, poor job control and negative interpersonal experiences with supervisors have been documented in primary healthcare. The work environment in primary healthcare is also affected by several types of changes.
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- The intestinal barrier serves as a crucial selective interface that separates the body's internal and external environments, and its compromise can lead to various health issues related to increased intestinal permeability (IP).
- Numerous studies, primarily identified through PubMed and Trip, examined the effects of prebiotics on IP between 2010-2023, but only six relevant studies were found, and results varied widely in design and population.
- Despite one study showing a significant positive effect of prebiotics on IP and some improvements in gut microbiota, there is a clear need for more comprehensive human studies with standardized methods to better understand the relationship between prebiotic interventions and IP.
Glycosylation is a unique posttranslational modification that dynamically shapes the surface of cells. Glycans attached to proteins or lipids in a cell or tissue are studied as a whole and collectively designated as a glycome. UniCarb-DB is a glycomic spectral library of tandem mass spectrometry (MS/MS) fragment data.
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