Publications by authors named "N Kandiah"
Article Synopsis
- Cerebral small vessel disease (SVD) can lead to various cerebrovascular issues, but research on sex differences in SVD is limited.
- This study analyzed data from over 20,000 patients with acute ischemic stroke to examine whether the presence and severity of cerebral microbleeds (CMB) and other SVD markers differ between males and females.
- Results showed that males had more frequent CMB while females had fewer lacunes but higher severe white matter hyperintensities, indicating distinct SVD characteristics based on sex.
Article Synopsis
- Motoric cognitive risk syndrome (MCR) is identified by slow walking speed and subjective memory complaints in older adults, and it may serve as an early warning sign for cognitive decline and dementia.
- A systematic review of 20 studies, involving over 1.2 million participants, found that those with MCR had more than double the risk of developing cognitive impairment and dementia compared to those without MCR.
- The findings suggest that MCR could be a valuable predictor of long-term cognitive issues, emphasizing the need for further research to confirm these associations.
Article Synopsis
- - This study investigates how various predictor domains contribute to predicting dementia in older adults and aims to improve a basic dementia risk prediction model (DRPM) by adding five different types of predictors.
- - Using data from the UK Biobank, the researchers collected 55 predictors grouped into clinical history, questionnaires, cognitive tests, genetic risk, and neuroimaging to analyze their impact on predicting all-cause dementia, Alzheimer's disease, and vascular dementia.
- - The findings showed that neuroimaging yielded the highest added value for predicting dementia types, suggesting that using a combination of different predictor domains can enhance prediction accuracy, although selecting predictors involves some trade-offs.
Neuropsychiatric symptoms (NPS) and mood disorders are common in individuals with mild cognitive impairment (MCI) and increase the risk of progression to dementia. Wearable devices collecting physiological and behavioral data can help in remote, passive, and continuous monitoring of moods and NPS, overcoming limitations and inconveniences of current assessment methods. In this longitudinal study, we examined the predictive ability of digital biomarkers based on sensor data from a wrist-worn wearable to determine the severity of NPS and mood disorders on a daily basis in older adults with predominant MCI.
View Article and Find Full Text PDFAdvances in biomarker-based diagnostic modalities, recent approval of anti-amyloid monoclonal antibodies for early Alzheimer's disease (AD; mild cognitive impairment or mild dementia due to AD) and late-stage clinical development of other disease-modifying therapies for AD necessitate a significant paradigm shift in the early detection, diagnosis and management of AD. Anti-amyloid monoclonal antibodies target the underlying pathophysiological mechanisms of AD and have demonstrated a significant reduction in the rate of clinical decline in cognitive and functional outcome measures in patients with early AD. With growing recognition of the benefit of early interventions in AD, an increasing number of people may seek diagnosis for their subjective cognitive problems in an already busy medical system.
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