Publications by authors named "N Kanaji"
Background: Despite the autoimmune nature of psoriasis, the potential association between psoriasis and interstitial lung disease (ILD) remains underexplored. This study aimed to investigate the frequency and clinical features of ILD in patients with psoriasis and propose a new conceptual framework of "ILD associated with psoriasis".
Methods: A retrospective analysis of 117 patients with psoriasis was conducted, excluding those without chest imaging prior to methotrexate or biologic use and those with other comorbidities leading to ILD.
Background: Lung cancer was often diagnosed by malignant pleural effusion (MPE). Excessive MPE is generally discarded. The establishment of cell lines and the generation of cancer mouse models have the potential to be directly linked to personalized medicine.
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- The study investigates the effectiveness of immune checkpoint inhibitors (ICI) for non-small cell lung cancer (NSCLC) patients, particularly comparing those with brain metastases (BM) to those without.
- It analyzes data from 240 patients, finding no major overall survival differences between the two groups, but identifies a significant survival disadvantage for patients with BM among those with high PD-L1 expression (≥50%).
- The conclusion suggests that while ICI is generally effective for both groups, patients with BM and high PD-L1 levels may have poorer outcomes compared to their counterparts without BM.
Article Synopsis
- Immune checkpoint inhibitors (ICIs) are standard treatment for advanced non-small cell lung cancer (NSCLC), and this study investigates the impact of upfront radiotherapy for brain metastases (BMs) in patients treated with either ICI alone or ICI plus chemotherapy.
- An analysis of 591 patients across multiple institutions revealed that those receiving upfront radiotherapy alongside ICI alone had significantly longer overall survival compared to those who did not receive radiotherapy.
- However, in the group treated with ICI-chemo, the addition of upfront radiotherapy did not show any significant survival benefit, suggesting different responses to treatment strategies.
Identifying programmed death-ligand-1 (PD-L1) expression is crucial for optimizing treatment strategies involving immune checkpoint inhibitors. However, the role of intratumoral metabolic heterogeneity specifically derived from F-fluorodeoxyglucose (FDG) positron emission tomography (PET) images in predicting PD-L1 expression in patients with newly diagnosed non-small cell lung cancer (NSCLC) remains unexplored. Here, we investigated the association between FDG PET texture features and PD-L1 expression by retrospectively analyzing the data of patients newly diagnosed with NSCLC who underwent FDG PET/CT scans and PD-L1 immunohistochemical staining before treatment.
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