Publications by authors named "N Kambe"
Kawasaki disease (KD) is an idiopathic acute inflammatory illness that commonly affects children in Northeast Asian countries. In this case report, a psoriasiform eruption appeared on the face and extremities following the onset of KD. A review of previous reports identified 38 cases of psoriasiform eruptions following KD, typically appearing 4 days to 2 months after the onset of KD, unlike other skin manifestations associated with the disease.
View Article and Find Full Text PDFThe Hashimoto Research Group for Comprehensive Research of Gene Mutation-related Rare and Intractable Diseases of the Skin is a contributor to the Project for Research on Intractable Diseases of the Ministry of Health, Labor, and Welfare (MHLW) of Japan. Our research group performs clinical research on 23 rare intractable genetic skin diseases that are classified into eight disease groups. Among the 23 diseases, 17 are mainly studied by our research group, and 6 diseases are studied in collaboration with other research groups.
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- Schnitzler syndrome is an adult-onset autoinflammatory condition presenting with a rash, fever, and fatigue, but lacks an approved treatment, prompting this study on canakinumab.
- In this phase II trial, five patients received a single dose of canakinumab, with the goal of achieving a complete clinical response (CR) and tracking improvements in quality of life and inflammatory markers.
- The results indicated that 60% of patients achieved CR by Day 7, and all patients demonstrated improvements in inflammation and quality of life, suggesting canakinumab may be beneficial for those with Schnitzler syndrome.
The synthesis of multifunctionalized dihydropyridinones from aldehydes and ketones involves at least a three-step process, making route shortening a challenging task, especially in achieving a one-pot four-component synthesis via aldehydes and ketones precondensation. Herein, we discovered a [1 + 2 + 1 + 2] four-component domino cyclization reaction, a novel concept in 4CRs with commercially available ketones and aldehydes, which by initially combining aldehydes and ketones with Meldrum's acid and ammonium acetate (NHOAc), respectively, they give dihydropyridones (>110 examples). This transformation features inexpensive additives and readily available starting materials, making it appropriate for rapid access to relevant pharmaceutical molecules containing dihydropyridinone-derived heterocycles.
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- The study investigates the phenomenon of basopenia (decreased basophils in blood) occurring during urticaria (allergic skin reaction), aiming to replicate this in an IgE-mediated mouse model.* -
- Using TNP-specific IgE and stimulation with TNP-ovalbumin, researchers observed immediate ear swelling and reduced basophils in the blood and skin lesions, while more basophils were found in the lymph nodes.* -
- Findings suggest that during urticaria, basophils migrate to lymph nodes as part of the immune response, indicating the need to consider systemic immune interactions while studying urticaria pathogenesis in humans.*