Publications by authors named "N Kalman"
Article Synopsis
- The study compares hypofractionated radiation therapy to standard fractionation in treating Merkel cell carcinoma (MCC), aiming to assess treatment outcomes and toxicity.
- A total of 29 treatment courses were reviewed from 24 patients, showing no significant differences in local or distant cancer recurrence, or overall survival between the two methods.
- The findings suggest that hypofractionated treatment is just as effective as standard fractionation, with the added benefit of requiring fewer sessions, but further research with a larger group is necessary to validate these results.
Article Synopsis
- The introduction of immune checkpoint inhibitors, like pembrolizumab, has improved treatment outcomes for head and neck squamous cell carcinoma (HNSCC), moving beyond traditional chemotherapy options.
- Combination therapies that include immunotherapy are being explored in clinical trials, and personalization based on tumor biomarkers is becoming crucial for optimizing treatment plans.
- There's a need for further clinical research and standardized guidelines, particularly concerning dental care and management of oral side effects, to enhance the effectiveness of immunotherapy in HNSCC patients.
Objectives: Clinical and imaging examinations frequently have indeterminate results during cancer surveillance, which can lead to overtreatment and cause psychological and financial harm to the patient. This study addresses the critical need to enhance diagnostic precision and decision-making in the management of HPV-associated oropharyngeal cancer. This study evaluated the utility of tumor tissue-modified viral (TTMV)-HPV DNA to resolve indeterminate disease status following definitive treatment for HPV-associated oropharyngeal cancer.
View Article and Find Full Text PDFBackground: Tubarial glands are a new organ at risk for head and neck cancer radiation therapy (RT). We aimed to study the feasibility of sparing them using intensity-modulated radiation therapy (IMRT).
Methods: Tubarial glands were delineated for 17 patients with oropharyngeal carcinoma receiving definitive RT, and treatment plans were re-optimized to spare dose to the tubarial glands while maintaining target coverage.