Peripheral memory B cells in multiple sclerosis vs. double negative B cells in neuromyelitis optica spectrum disorder: disease driving B cell subsets during CNS inflammation.

B cells are fundamental players in the pathophysiology of autoimmune diseases of the central nervous system, such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). A deeper understanding of disease-specific B cell functions has led to the differentiation of both diseases and the development of different treatment strategies. While NMOSD is strongly associated with pathogenic anti-AQP4 IgG antibodies and proinflammatory cytokine pathways, no valid autoantibodies have been identified in MS yet, apart from certain antigen targets that require further evaluation.

Hemolytic Activity and Cytotoxicity of Synthetic Nanoclays with Montmorillonite Structure for Medical Applications.

The factors influencing the appearance of toxicity in samples of synthetic montmorillonite with a systematically changing chemical composition Na(Al, Mg)SiO(OH) nHO, which are potentially important for their use in medicine as drug carriers, targeted drug delivery systems, entero- and hemosorbents have been studied. Samples synthesized under hydrothermal conditions had the morphology of nanolayers self-organized into the nanosponge structures. The effect of the aluminum content, particle sizes, porosity, and ζ-potential of the samples on their toxicity was studied.

Synthesis of Multifunctional Oligomethylsilsesquioxanes by Catalyst-Free Hydrolytic Polycondensation of Methyltrimethoxysilane under Microwave Radiation.

The catalyst-free hydrolytic polycondensation of methyltrimethoxysilane under microwave radiation has been studied. The effect of molar ratios of the reagents (MTMS/HO = 1/0.5-1/9), radiation power (20-300 W), temperature (30-50 °C) and duration of exposure (2.

Ring-Opening Polymerization (ROP) and Catalytic Rearrangement as a Way to Obtain Siloxane Mono- and Telechelics, as Well as Well-Organized Branching Centers: History and Prospects.

PDMS telechelics are important both in industry and in academic research. They are used both in the free state and as part of copolymers and cross-linked materials. At present, the most important, practically used, and well-studied method for the preparation of such PDMS is diorganosiloxane ring-opening polymerization (ROP) in the presence of nucleophilic or electrophilic initiators.

Multiarm Star-Shaped Polydimethylsiloxanes with a Dendritic Branching Center.

New multiarm stars have been synthesized based on polylithium derivatives of high-generation carbosilane dendrimers. In the synthesis of multiarm stars based on the eighth-generation dendrimer, steric hindrances were observed even during the synthesis of a polylithium initiator. Subsequently, this led to chain transfer reactions between growing arms, as well as other side effects.