[Effect of diucifon on the natural cytotoxic activity of splenic cells in old rats].

The results of comparative investigation of diucifon effect on the level of natural killer cell activity in young and old mice are presented. An increase in the natural cytotoxic activity, as indicated by 51Cr-release micro-test, was considerably higher in old than in young mice during 1-3 days after diucifon administration. However, after diucifon stimulation the level of natural killer cell activity in old mice was significantly lower than in intact young mice.

[Retrograde degeneration of the neurons of the cerebellar nuclei after partial removal of the associative cerebral cortex].

Retrograde degeneration of the cerebellar nuclei cells has been studied after partial ablation of the associative parietal cerebral cortex in the cat. The material is stained after Nissl. Retrogradely degenerated and normal cells are counted.

[Analysis of changes in natural cytostatic and cytotoxic activity of mouse spleen cells after treatment with cyclophosphamide and alpha-interferon].

Cytostatic and cytotoxic activity of mouse spleen cells against normal and tumour target cells has been studied. The comparative analysis of mouse spleen cell cytostatic and cytotoxic activity after exposure to cyclophosphamide has shown that the effectors of natural cytotoxic activity are highly sensitive to cyclophosphamide, while cytostatic effectors are heterogeneous in their sensitivity to cyclophosphamide. Pretreatment of spleen cells with alpha-interferon produced an increase in cytotoxic and cytostatic activity against tumour target cells.