Mangiferin promotes porcine oocyte maturation and delays the postovulatory aging process by up-regulating NRF2 levels.

Mangiferin (MGN), a flavonoid known for its anti-inflammatory and antioxidant properties, was evaluated in this study for its effects on porcine oocyte maturation in vitro, as well as its potential to modulate the mechanisms associated with aging oocytes. The inclusion of 0.1 μM MGN in the IVM culture medium significantly enhanced blastocyst development following parthenogenetic activation, while also notably upregulating the expression of key embryonic development genes, including SOX2, PCNA, POU5F1, and DNMT3A.

The Uneven Playing Field: Provider Participation and Regional Disparities in Oral Health Examination Rates in South Korea.

Objectives: This study investigated regional disparities in adult oral health examination rates in South Korea, despite free oral health screenings by the National Health Insurance Service (NHIS). It focused on the impact of provider factors, such as the availability of dental clinics and non-dental institutions.

Methods: A cross-sectional analysis of 2022 data from 229 districts was conducted.

Dynamic WNT signaling controls differentiation of hematopoietic progenitor cells from human pluripotent stem cells.

Human pluripotent stem cells (hPSCs) can in theory give rise to any hematopoietic lineages, thereby offering opportunities for disease modeling, drug screening and cell therapies. However, gaps in our knowledge of the signaling requirements for the specification of human hematopoietic stem/progenitor cells (HSPCs), which lie at the apex of all hematopoietic lineages, greatly limit the potential of hPSC in hematological research and application. Transcriptomic analysis reveals aberrant regulation of WNT signaling during maturation of hPSC-derived hematopoietic progenitor cells (hPSC-HPCs), which results in higher mitochondria activity, misregulation of HOX genes, loss of self-renewal and precocious differentiation.

Organic Radical-Boosted Ionic Conductivity in Redox Polymer Electrolyte for Advanced Fiber-Shaped Energy Storage Devices.

Fiber-shaped energy storage devices (FSESDs) with exceptional flexibility for wearable power sources should be applied with solid electrolytes over liquid electrolytes due to short circuits and leakage issue during deformation. Among the solid options, polymer electrolytes are particularly preferred due to their robustness and flexibility, although their low ionic conductivity remains a significant challenge. Here, we present a redox polymer electrolyte (HT_RPE) with 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (HT) as a multi-functional additive.

Quality Analysis of YouTube-Based Exercise Programs for Typically Developing Children: Content Analysis.

Physical activities in childhood are important. However, a lack of exercise among children and adolescents is becoming a global reality. Moreover, following the coronavirus disease 2019 pandemic, the increase in time spent at home has led to qualitative changes, such as at-home exercises and the use of YouTube content.