Publications by authors named "N K Hutson"
Remote Work Support Needs of Employees with Autism Spectrum Disorder in Poland: Perspectives of Individuals with Autism and Their Coworkers.
Int J Environ Res Public Health
September 2022
Background And Aims: With remote work becoming more common across industries, employees with autism may experience different work support needs from neurotypical peers. However, the specific remote work needs of this group of employees are underexplored in the literature. We aim to propose ways to assess workplace digital adaptation needs for individuals with autism and a framework for communicating these needs to employers.
View Article and Find Full Text PDFSpatial heterogeneity is a common phenomenon in metastatic solid tumors and an evolving concept in multiple myeloma (MM). The interplay between malignant plasma cells (PCs) and the microenvironment has not yet been analyzed in MM. For this purpose, we performed bone marrow aspirates and imaging-guided biopsies of corresponding lesions in newly diagnosed MM (NDMM) and relapsed/refractory MM (RRMM) patients.
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- Osteolytic lesions (OL) in multiple myeloma are influenced by malignant plasma cells (PC), but the reasons for varying bone destruction in different regions remain unclear.
- A study using single-cell RNA sequencing analyzed 148,630 PC from various sites in 10 patients, revealing significant inter- and intra-patient variability.
- Findings indicate that PC from OL express different genes compared to those from bone marrow, highlighting specific gene changes related to bone disease and showing transcriptional shifts post-induction therapy.
Article Synopsis
- Multi-sample comparison is essential in cancer genomics to determine mutation statuses, but low coverage can lead to false negatives, making it necessary to classify uncertain results as "unknown" instead of "negative."
- The study proposes an adaptive mutation-specific negative (MSN) method, which assesses the frequency of mutant reads by comparing non-positive samples to known positives, ensuring accurate classification of mutation statuses.
- The results show that the MSN method outperforms the traditional universal minimum coverage (UMC) approach in both simulated and real datasets, leading to more accurate negative status assignments and increased data availability.
In ultraviolet (UV) radiation-exposed skin, mutations fuel clonal cell growth. The relationship between UV exposure and the accumulation of clonal mutations (CMs) and the correlation between CMs and skin cancer risk are largely unexplored. We characterized 450 individual-matched sun-exposed (SE) and non-SE (NE) normal human skin samples.
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