[Features of fibrosis and disorders of the collagen metabolism of the interstitial matrix of the myocardium in patients with arterial hypertension and possibilities of their correction with sartname.].

Metabolic disorders of the interstitial heart and vessels matrix in hypertension develop due to chronic stretching of their walls. For estimation the involutive and hypertensive changes in interstitial matrix of the heart and vessels we have been examined 30 normotensive elderly women and 30 patients of same age with arterial hypertension (AH) II stage, as well as the possibility of their correction by valsartan and veroshpiron. The next parameters of investigation used: the volume fraction of interstitial collagen (VFIC) in myocardium, cardiovascular conjugation (CVC), serum concentrations of markers of systemic collagenogenesis - COL-1, TGF-β1, MMP-1, TIMP-1, Gal-3.

[Involutive and hypertensive fibrosive transformation of the heart in formation of myocardial dysfunction and chronic heart failure.].

To assess the conjugation of involutive and hypertensive fibrotic transformation of the heart formation with myocardial dysfunction and chronic heart failure (CHF), 30 normotensive individuals and 60 elderly patients with arterial hypertension (AH) (mean age - 66±0,7 years) were examined by echo and dopplercardiography, estimation of the volume fraction of interstitial collagen (VFIC) in the myocardium, serum concentrations of markers of systemic collagenogenesis, using a six-minute walk test. A higher intensity of LV myocardial fibrosis was revealed with a significant increase in the VFIC content in elderly patients with AH compared with normotensive patients, which indicates the predominance of interstitial collagenogenesis over collagenolysis. The increased content of fibrous tissue in myocardial interstitium caused the development of unfavorable types of cardiac remodeling and the progression of diastolic dysfunction, negatively affecting the functional reserve of the circulatory system, as evidenced by negative correlations between the level of the VFIC and the results of a 6-minute walk test: weak in patients with I FC CHF, moderate strength in patients with AH with II FC CHF.

[Correction of anxiety-depressive disorders in Parkinson's Disease.].

In the formation of a common age-associated pathological process in patients with Parkinson's disease along with movement disorders so-called «non-motorized» clinical symptoms (including anxiety and depression) play an important role. These pathological manifestations can reduce the quality of life of the patient and require specific therapeutic measures. The picker is the use of drugs - antidepressants.

[The state of geriatric care in the Kursk region: problems of formation and development prospects.].

The article presents the main promising directions for the development of geriatric care for the elderly population implemented in the Kursk region thanks to the efforts of the Polyclinic Therapy and General Practice Department of the Kursk State Medical University, the Kursk Branch of the Gerontological Society of the Russian Academy of Sciences, and the team of the Kursk Local Center of the Global Aging Network for the International Association Gerontology and geriatrics, consisting in the professional retraining of specialists for working with the elderly population, providing quality advisory services to specialists of outpatient medical institutions, organizing scientific and practical conferences devoted to the discussion of urgent problems of gerontology and geriatrics, effective cooperation with the service of social protection of the population. The important role of training qualified medical staff, conducting modern scientific research, introducing their results into healthcare practice, the need to organize additional education for the elderly, involving them in performing volunteer activities to maintain a functional socially-demanded activity, and quality of life are emphasized.

[Significance of insulin resistance in the pathogenesis of sarcopenia and chronic heart failure in elderly hypertensive patients].

To determine the pathogenic role of insulin resistance in the formation of involutive sarcopenia and chronic heart failure (CHF) were examined 88 elderly patients with arterial hypertension (AH) and 32 elderly patients without cardiovascular disease by methods of carbohydrate metabolism and the level of brain natriuretic peptide precursor evaluation, muscle mass and strength measuring, echocardiography, 6 minute walking test. It was found that in the group of hypertensive patients with low mass and muscle strength significantly increased indices of insulin resistance and more expressed signs of the left ventricle myocardial dysfunction and functional class of heart failure, probably as a result of disorders of energy homeostasis, resulting from the deterioration of glucose into the muscle cells of the heart and skeletal muscles.