P-selectin inhibition therapeutically promotes thrombus resolution and prevents vein wall fibrosis better than enoxaparin and an inhibitor to von Willebrand factor.

Objective: Aptamers are oligonucleotides targeting protein-protein interactions with pharmacokinetic profiles and activity reversal options. Although P-selectin and von Willebrand factor (vWF) have been implicated in the development of venous thrombosis (VT), no studies have directly compared aptamer efficacy with standard of care in VT. In this study, ARC5692, an anti-P-selectin aptamer, and ARC15105, an anti-vWF aptamer, were compared with low-molecular-weight heparin, enoxaparin, to test the efficacy of P-selectin or vWF inhibition in promoting thrombus resolution and preventing vein wall fibrosis, in a baboon model of VT.

Physiologic variations in venous and arterial hemodynamics in response to postural changes at the thoracic outlet in normal volunteers.

Background: Hemodynamic changes in vascular flow and waveforms measured across the thoracic outlet (TO) during positional changes may occur in normal individuals. The aim of this study was to establish the prevalence of significant arterial and venous hemodynamic variation in the limbs of normal volunteers during standardized upper extremity positional changes.

Methods: Using Doppler ultrasound and photoplethysmography (PPG), we evaluated arterial and venous flow in 100 limbs of 50 normal volunteers in neutral position and in 5 different standardized arm positions, including 90° arm abduction (with head in neutral position, head turned ipsilaterally, and head turned contralaterally), arm extended above the head at 180°, and arm hyperextended at 200°.