Postoperative chylous ascites successfully managed by selective lymphatic embolization: Case report and literature review.

Postoperative chylous ascites is a rare complication following retroperitoneal surgeries, presenting significant challenges in diagnosis and management. Retroperitoneal cyst surgery resulting in chylous leaks is an uncommon complication that has not been previously reported in the literature. Therefore, we report a clinical case of postoperative chylous ascites following retroperitoneal cyst removal with underlying idiopathic thoracic duct obstruction.

MDM2 up-regulates the energy metabolism in NSCLC in a p53-independent manner.

Although an E3 ligase MDM2 is the major negative regulator of the p53 tumor suppressor, a growing body of evidence suggests its p53-independent oncogenic properties. In particular, MDM2 has been shown to regulate serine metabolism independently of p53 status in several types of neoplasia, including NSCLC. Using the GSEA approach and publicly available molecular data on NSCLC tumors, our bioinformatics data suggest that MDM2 affects a number of metabolic genes, particularly those encoding components of the electron transport chain (ETC).

Levofloxacin for the Prevention of Multidrug-Resistant Tuberculosis in Vietnam.

Background: Prevention of drug-resistant tuberculosis is a global health priority. However, trials evaluating the effectiveness of treating infection among contacts of persons with drug-resistant tuberculosis are lacking.

Methods: We conducted a double-blind, randomized, controlled trial comparing 6 months of daily levofloxacin (weight-based doses) with placebo to treat infection.

An Oxazole Alkaloid, Terpenoids, and Cyclodipeptides with Cytotoxic and NO Inhibitory Effects from a Mangrove-Derived Fungus Trichoderma sp. GXT-22.1.

Chemical investigation of the mangrove-derived fungus Trichoderma sp. GXT-22.1 led to isolation and identification of 10 secondary metabolites, including one new compound, 5'-(4-methoxyphenyl)-1',3'-oxazole (1), one new natural compound, (E)-6,10-dimethyl-5-undecene-2,9,10-triol (2), along with eight known compounds, tricholumin A (3), harzianol J (4), cyclonerodiol (5), 10,11-dihydro-11-hydroxycyclonerodiol (6), cyclonerodiol B (7), epicyclonerodiol oxide (8), cyclo(Val-Pro) (9), and cyclo-(4-hydroxyprolinyl-leucine) (10).

Culcinoside E, a new sulfated steroidal biglycoside from the starfish .

Using various chromatographic separations, six steroid glycoside derivatives, including one new compound named culcinoside E (), were isolated from the methanol extract of the starfish . Their structures were confirmed by detailed analysis of the 1D, 2D NMR, and HR ESI QTOF mass spectra. Among isolated compounds, culcinoside E (), diplasterioside A (), and thornasteroside A () inhibited growth of , whereas culcitoside C () was active on .