Publications by authors named "N Juretic"
Article Synopsis
- Four main molecular subtypes of medulloblastoma (MB) have been identified, but the differences in their 3D genome architecture remain unclear.
- To investigate this, researchers used a technique called in situ Hi-C to create detailed 3D genome maps from 28 surgical MB samples and one patient-derived xenograft.
- The findings revealed that differences in insulation scores of topologically associating domains (TADs) can effectively differentiate MB subtypes, indicating that these differences occur independently of the subtypes' gene expression levels.
Histone H3-mutant gliomas are deadly brain tumors characterized by a dysregulated epigenome and stalled differentiation. In contrast to the extensive datasets available on tumor cells, limited information exists on their tumor microenvironment (TME), particularly the immune infiltrate. Here, we characterize the immune TME of H3.
View Article and Find Full Text PDFPosterior fossa group A (PFA) ependymoma is a lethal brain cancer diagnosed in infants and young children. The lack of driver events in the PFA linear genome led us to search its 3D genome for characteristic features. Here, we reconstructed 3D genomes from diverse childhood tumor types and uncovered a global topology in PFA that is highly reminiscent of stem and progenitor cells in a variety of human tissues.
View Article and Find Full Text PDFIncrease in body fat contributes to loss of function and changes in skeletal muscle, accelerating sarcopenia, a phenomenon known as sarco-obesity or sarcopenic obesity. Studies suggest that obesity decreases the skeletal muscle (SM)'s ability to oxidize glucose, increases fatty acid oxidation and reactive oxygen species production, due to mitochondrial dysfunction. Exercise improves mitochondrial dysfunction in obesity; however, it is not known if exercise regulates the mitochondrial unfolded protein response (UPRmt) in the SM.
View Article and Find Full Text PDFArticle Synopsis
- Juvenile Pilocytic Astrocytomas (JPAs) are common pediatric brain tumors linked to abnormal activation of the MAPK signaling pathway, primarily due to RAF-fusions like KIAA1549-BRAF, leading to challenges in detecting gene fusions because of mixed immune cell presence.
- New methods like RNA-Seq, linked-read whole-genome sequencing, and in situ Hi-C were employed to identify and analyze low-frequency gene fusions specific to JPAs, resulting in the discovery of new BRAF fusion partners (PTPRZ1 and TOP2B) alongside the known KIAA1549 fusion.
- The research highlights the effectiveness of integrating multiple genomic datasets to better understand JPA genetics and suggests that these innovative techniques could be valuable