A general framework dedicated to computational morphogenesis Part I - Constitutive equations.

In order to understand living organisms, considerable experimental efforts and resources have been devoted to correlate genes and their expressions with cell, tissue, organ and whole organisms' phenotypes. This data driven approach to knowledge discovery has led to many breakthrough in our understanding of healthy and diseased states, and is paving the way to improve the diagnosis and treatment of diseases. Complementary to this data-driven approach, computational models of biological systems based on first principles have been developed in order to deepen our understanding of the multi-scale dynamics that drives normal and pathological biological functions.

Computational morphogenesis - Embryogenesis, cancer research and digital pathology.

Overall survival benefits of cancer therapies have, in general, fallen short of what was expected from them. By examining the many parallels that exist between embryogenesis and carcinogenesis, we discuss how clinical and fundamental cancer research can benefit from computational morphogenesis (CM) insofar as carcinogenesis is causally related to altered mechanisms underlying embryogenesis and post-embryonic tissue homeostasis. We also discuss about the critical role played by digital pathology (DP) since it constitutes the main source of data for the model-fitting and validation of CM-generated virtual tissues.

An ECG analysis interactive training system for understanding arrhythmias.

The ECG remains a daily diagnostic tool for the detection of numerous cardiovascular diseases. Our goal was to use a computerized qualitative model (QM) of heart in order to build cases of simple arrhythmias dedicated to initial and more advanced medical teaching. The original QM is able to generate videograms of many cardiac disturbances.

Multimedia and physiology: a new way to ensure the quality of medical education and medical knowledge.

Background: since the eighties and the existence of virtual campuses, the value of computers in distance education has been acknowledged. The development of information and communication technologies is driving at discriminating distance education and on-line education.

Purpose: the aim of the "Campus Numérique de Physiologie" is not to reproduce an on-line copy of classical textbooks but to put at students' and physicians' disposal the huge possibilities of multimedia resources for an active and easier understanding of complex physiopathological phenomena.