A case of improved quality of life in a patient with inoperable pancreatic cancer after repeated RFA.

Radiofrequency ablation (RFA) has widespread popularity due to its immune-modulation effects in many cancers. Optimal settings to apply RFA in pancreatic cancer, in which the advanced stage of the tumor at the diagnosis makes various therapeutic approaches fail, are still demanding. We report the case of a patient with unresectable pancreatic cancer in which 3 repetitive RFA has been applied over a period of 3 months.

Efficiency of human monocyte-derived suppressor cell-based treatment in graft-versus-host disease prevention while preserving graft-versus-leukemia effect.

Background: Immunosuppressive cell-based therapy is a recent strategy for controlling Graft--Host Disease (GvHD). Such cells ought to maintain their suppressive function in inflammatory conditions and in the presence of immunosuppressive agents currently used in allogeneic hematopoietic cell transplantation (allo-HCT). Moreover, these therapies should not diminish the benefits of allo-HCT, the Graft--Leukemia (GvL) effect.

EFFECTS OF DIFFERENT TREATMENT OPTIONS ON THE LEVEL OF SERUM CYTOKINES IN PATIENTS WITH LIVER CANCER.

Liver cancer is a highly lethal cancer, in which local tumor microenvironment and systemic immune suppression allow tumor to escape immune surveillance. Intervening in tumor microenvironment by locoregional treatment options can be beneficial for patients. We aimed to study changes in serum cytokines levels due to local disturbance of tumor microenvironment after radiofrequency thermal ablation procedure compare to liver resection in patients with primary and metastatic liver cancer.

PERIPHERIAL BLOOD BIOMARKERS IN PATIENTS WITH REFRACTORY IMMUNE THROMBOCYTOPENIA.

Immune thrombocytopenia is an acquired thrombocytopenia caused by autoantibodies against platelet antigens, the pathogenesis of ITP is incompletely understood. Evidence regarding association between inflammatory factors in patients with ITP who are refractory to first line treatment is limited.The purpose of our study was to investigate the diagnostic value of NLR, PLR, and PMR, dNLR, and SII in ITP patients who were refractory for the first line treatment and had splenectomy as a second-line therapy.