Publications by authors named "N J van der Put"
Article Synopsis
- * A study of 10 cases revealed that this translocation connects the interferon regulatory factor 4 (IRF4) gene on chromosome 6 with the regulator of chromosome condensation 1 (RCC1) gene on chromosome 1, resulting in fusion transcripts.
- * Despite the fusion, the expression levels of RCC1 and IRF4 proteins remained normal, and the cases also displayed typical mutations related to CLL, suggesting a linkage with the IGHV-unmutated subtype.
Breast-implant associated (BIA) lymphoma is an infrequent type of cancer occurring in the fluid and fibrous capsule around a textured breast implant. Recently, both the 2022 WHO 5th edition classification of Haematological tumours (WHO HAEM5) and 2022 International Consensus Classification of Mature Lymphoid Neoplasms (22ICC), recognized breast implant-associated Anaplastic Large Cell Lymphoma (BIA-ALCL) as a definitive entity, defined as a mature CD30-positive T-cell lymphoma, confined by a fibrous capsule, in a breast implant setting. Only few B-cell lymphomas have been reported in the literature to be associated with breast implants.
View Article and Find Full Text PDFWe present the case of a 67-year-old woman who suffered recurrent episodes of angioedema of the face and larynx. After thorough biochemical investigations, an acquired deficiency of C1-INH was suspected. To evaluate a potential underlying malignancy, a whole-body FDG-PET/CT was performed and showed solely a marked splenomegaly pointing towards a splenic marginal zone lymphoma, which was confirmed by pathological examination.
View Article and Find Full Text PDFObjectives: To assess interruptions/discontinuations of tyrosine kinase inhibitor (TKI) treatment in Belgian patients with chronic myeloid leukaemia (CML).
Methods: This retrospective study included patients with TKI interruptions/discontinuations of ≥4 continuous weeks (no clinical trial context) between May 2013 and May 2016. Data collection took place between October 2016 and February 2017.