Publications by authors named "N J Welton"
Background: Latent class models can be used to estimate diagnostic accuracy without a gold standard test. Early studies often assumed independence between tests given the true disease state, however this can lead to biased estimates when there are inter-test dependencies. Residual correlation plots and chi-squared statistics have been commonly utilized to assess the validity of the conditional independence assumption and, when it does not hold, identify which test pairs are conditionally dependent.
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- Stroke patients on clopidogrel may face risks from genetic variants that impair how their bodies process the medication; genetic testing can help identify these issues for better treatment targeting.* -
- The study examined whether genetic testing for clopidogrel resistance can lead to a lower risk of future vascular events, especially when using alternative medications like ticagrelor instead of clopidogrel.* -
- Results showed that while two studies indicated a reduced risk of events in genetically tested patients, the evidence was not very strong, and ticagrelor was found to be more effective than clopidogrel in those with genetic variants.*
Background: Various effective treatments for depression exist. We aimed to identify the most effective first-line treatments for new episodes of less and more severe depression (defined by depression scale cut-off scores), to update NICE guidance on the management of Depression in Adults in England.
Methods: Systematic review and network meta-analysis of randomised controlled trials (RCTs) published up to June 2020 (PROSPERO registration number CRD42019151328).
To assess the accuracy and technical characteristics of point of care tests (POCTs). Systematic review of primary studies, in any population or setting, that evaluated POCTs for detecting loss of function (LOF) alleles. Eleven studies provided accuracy data (eight Spartan; one Genomadix Cube; one GMEX; one Genedrive).
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